Daithi S Heffernan
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Explore the profile of Daithi S Heffernan including associated specialties, affiliations and a list of published articles.
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76
Citations
832
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Recent Articles
1.
Khedr S, Hong J, Forter-Chee-A-Tow N, Cygiel G, Heffernan D, Lee B, et al.
J Surg Res
. 2024 Jul;
301:352-358.
PMID: 39024714
Introduction: Currently, there is no mandatory standard for reporting race and ethnicity in medical journals, presenting significant barriers to studying disparities in medical outcomes. We seek to investigate whether greater...
2.
Huston J, Barie P, Dellinger E, Forrester J, Duane T, Tessier J, et al.
Surg Infect (Larchmt)
. 2024 Jul;
25(6):419-435.
PMID: 38990709
The Surgical Infection Society (SIS) published evidence-based guidelines for the management of intra-abdominal infection (IAI) in 1992, 2002, 2010, and 2017. Here, we present the most recent guideline update based...
3.
invariant Natural Killer T Cells Modulate the Peritoneal Macrophage Response to Polymicrobial Sepsis
Heffernan D, Chun T, Monaghan S, Chung C, Ayala A
J Surg Res
. 2024 Jun;
300:211-220.
PMID: 38824851
Introduction: A dysregulated immune system is a major driver of the mortality and long-term morbidity from sepsis. With respect to macrophages, it has been shown that phenotypic changes are critical...
4.
Ciambella C, Witt H, Dickinson C, Smith M, Coburn N, Messina N, et al.
Shock
. 2024 May;
62(2):165-172.
PMID: 38813923
Background: The recruitment of neutrophils to sites of localized injury or infection is initiated by changes on the surface of endothelial cells located in proximity to tissue damage. Inflammatory mediators,...
5.
Heffernan D, Chung C, Ayala A
Inflamm Res
. 2023 Dec;
73(1):1-4.
PMID: 38147124
Background: iNKT-cells are innate regulatory lymphocytes capable of directing immune and inflammatory responses to sepsis. Repeat stimulation of iNKT-cells leads to the induction of anergy with the emergence of a...
6.
Heffernan D, Chung C, Ayala A
Shock
. 2023 Jul;
60(3):443-449.
PMID: 37493576
Background: Sepsis is marked by a dysregulated immune response to an infection. Invariant natural killer T cells ( i NKT cells) are a pluripotent lymphocyte subpopulation capable of affecting and...
7.
Khetpal V, Berkowitz J, Jiang L, Menon A, Shah N, Heffernan D, et al.
JACC Adv
. 2023 Jun;
:100381.
PMID: 37359237
No abstract available.
8.
Wakeley M, Armstead B, Gray C, Tindal E, Heffernan D, Chung C, et al.
Front Med (Lausanne)
. 2023 Jun;
10:1176602.
PMID: 37305124
Introduction: The co-regulatory molecule, HVEM, can stimulate or inhibit immune function, but when co-expressed with BTLA, forms an inert complex preventing signaling. Altered HVEM or BTLA expression, separately have been...
9.
Lin E, Heffernan D
R I Med J (2013)
. 2023 May;
106(5):34-37.
PMID: 37195159
Small bowel obstructions are common surgical presentations that are most often caused by adhesions following abdominopelvic surgeries. However, in patients with no history of abdominal surgical interventions, assessment of the...
10.
Simon K, Cournoyer L, Nwaiwu C, Stephen A, Heffernan D
R I Med J (2013)
. 2023 Apr;
106(4):46-51.
PMID: 37098148
Background: Acute Appendicitis (AA), one of the most common surgical emergencies, is usually managed operatively. There is a paucity of data addressing how HIV/AIDS affects management of acute uncomplicated appendicitis....