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Dabbu Kumar Jaijyan

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Articles 19
Citations 139
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Recent Articles
1.
Jaijyan D, Yang S, Ramasamy S, Gu A, Zeng M, Subbian S, et al.
Nucleic Acids Res . 2024 Jul; 52(15):e70. PMID: 39051561
We present a robust approach for cellular detection, imaging, localization, and quantification of human and viral encoded circular RNAs (circRNA) using amplified fluorescence in situ hybridization (ampFISH). In this procedure,...
2.
Banda A, Impomeni O, Singh A, Baloch A, Hu W, Jaijyan D
Vaccines (Basel) . 2024 Jun; 12(6). PMID: 38932365
Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-associated enzyme-CAS holds great promise for treating many uncured human diseases and illnesses by precisely correcting harmful point mutations and disrupting disease-causing genes. The...
3.
Yang S, Cao D, Jaijyan D, Wang M, Liu J, Cruz-Cosme R, et al.
Nat Commun . 2024 Jun; 15(1):4932. PMID: 38858365
This study investigates the role of circular RNAs (circRNAs) in the context of Varicella-Zoster Virus (VZV) lytic infection. We employ two sequencing technologies, short-read sequencing and long-read sequencing, following RNase...
4.
Liu J, Jaijyan D, Chen Y, Feng C, Yang S, Xu Z, et al.
Microbiol Spectr . 2023 Nov; 11(6):e0246323. PMID: 37971259
Cytomegalovirus (CMV) has been used as a novel viral vector for vaccine development and gene therapy. Coronavirus disease 2019 is an infectious disease caused by the SARS-CoV-2 virus, which is...
5.
Zeng J, Jaijyan D, Yang S, Pei S, Tang Q, Zhu H
Viruses . 2023 Oct; 15(10). PMID: 37896820
Viral vectors have emerged as powerful tools for delivering and expressing foreign genes, playing a pivotal role in gene therapy. Among these vectors, cytomegalovirus (CMV) stands out as a promising...
6.
Zeng J, Cao D, Yang S, Jaijyan D, Liu X, Wu S, et al.
Viruses . 2023 Aug; 15(8). PMID: 37632045
Human cytomegalovirus (HCMV) is a widespread pathogen that poses significant risks to immunocompromised individuals. Its genome spans over 230 kbp and potentially encodes over 200 open-reading frames. The HCMV transcriptome...
7.
Gu A, Jaijyan D, Yang S, Zeng M, Pei S, Zhu H
Noncoding RNA . 2023 Jul; 9(4). PMID: 37489458
Circular RNAs (circRNAs) represent single-stranded RNA species that contain covalently closed 3' and 5' ends that provide them more stability than linear RNA, which has free ends. Emerging evidence indicates...
8.
Ai Y, Wu C, Zhang M, Jaijyan D, Liu T, Zan L, et al.
Microbiol Spectr . 2022 Nov; 10(6):e0139322. PMID: 36342276
Human cytomegalovirus (HCMV) infects 36% to almost 100% of adults and causes severe complications only in immunocompromised individuals. HCMV viral surface trimeric (gH/gL/gO) and pentameric (gH/gL/UL128/UL130/UL131A) complexes play important roles...
9.
Jaijyan D, Govindasamy K, Lee M, Zhu H
Cell Rep Methods . 2022 Sep; 2(9):100287. PMID: 36160049
The development of a chemically attenuated, replication-incompetent virus vaccine can provide protection against diseases caused by DNA viruses. In this study, we have developed a method to produce live-attenuated, replication-defective...
10.
Li Z, Zhang X, Ho W, Bai X, Jaijyan D, Li F, et al.
Adv Funct Mater . 2022 Aug; 32(40):2204462. PMID: 35942271
SARS-CoV-2 has led to a worldwide pandemic, catastrophically impacting public health and the global economy. Herein, a new class of lipid-modified polymer poly (β-amino esters) (L-PBAEs) is developed via enzyme-catalyzed...