D R Grubb
Overview
Explore the profile of D R Grubb including associated specialties, affiliations and a list of published articles.
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6
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530
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Recent Articles
1.
Woodcock E, Grubb D, Iliades P
Curr Drug Targets
. 2010 Apr;
11(8):1032-40.
PMID: 20426766
Heart failure, the common end-point of many cardiac diseases, is a major contributor to mortality and morbidity and contributes considerably to health care costs. Current treatment regimens include beta-adrenergic antagonists,...
2.
Ly J, Grubb D, Lawen A
Apoptosis
. 2003 May;
8(2):115-28.
PMID: 12766472
Mitochondrial dysfunction has been shown to participate in the induction of apoptosis and has even been suggested to be central to the apoptotic pathway. Indeed, opening of the mitochondrial permeability...
3.
Baker M, Grubb D, Lawen A
Apoptosis
. 2002 Sep;
7(5):407-12.
PMID: 12207173
We have previously shown that didemnin B, a branched cyclic depsipeptide composed of seven amino acids and two hydroxy acids, can induce rapid and complete apoptosis in HL-60 cells (Grubb,...
4.
Grubb D, Ly J, Vaillant F, Johnson K, Lawen A
Oncogene
. 2001 Aug;
20(30):4085-94.
PMID: 11494136
Permeability transition, and a subsequent drop in mitochondrial membrane potential (DeltaPsi(m)), have been suggested to be mechanisms by which cytochrome c is released from the mitochondria into the cytosol during...
5.
Johnson K, Grubb D, Lawen A
J Cell Biochem
. 1999 Feb;
72(2):269-78.
PMID: 10022509
Caspases have been implicated in the induction of apoptosis in most systems studied. The importance of caspases for apoptosis was further investigated using the system of didemnin B-induced apoptosis. We...
6.
Grubb D, Wolvetang E, Lawen A
Biochem Biophys Res Commun
. 1995 Oct;
215(3):1130-6.
PMID: 7488040
Didemnin B, a cyclic N-methylated peptolide induces apoptosis in human HL-60 cells. When incubated with 1 microM didemnin B, unsynchronized HL-60 cultures undergo apoptosis to 100% within 140 minutes. Apoptosis...