D M Eccles
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Explore the profile of D M Eccles including associated specialties, affiliations and a list of published articles.
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56
Citations
2433
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Recent Articles
11.
Wilson J, Bateman A, Hanson H, An Q, Evans G, Rahman N, et al.
J Med Genet
. 2010 Sep;
47(11):771-4.
PMID: 20805372
Introduction: The Li-Fraumeni Syndrome is caused by a germline TP53 mutation and is associated with a high risk of breast cancer at young ages. Basal (triple negative) breast cancers are...
12.
Antoniou A, Cunningham A, Peto J, Evans D, Lalloo F, Narod S, et al.
Br J Cancer
. 2008 Mar;
98(8):1457-66.
PMID: 18349832
Multiple genetic loci confer susceptibility to breast and ovarian cancers. We have previously developed a model (BOADICEA) under which susceptibility to breast cancer is explained by mutations in BRCA1 and...
13.
Antoniou A, Pharoah P, Narod S, Risch H, Eyfjord J, Hopper J, et al.
J Med Genet
. 2005 Jul;
42(7):602-3.
PMID: 15994883
A recent report estimated the breast cancer risks in carriers of the three Ashkenazi founder mutations to be higher than previously published estimates derived from population based studies. In an...
14.
15.
Bunyan D, Eccles D, Sillibourne J, Wilkins E, Thomas N, Shea-Simonds J, et al.
Br J Cancer
. 2004 Oct;
91(6):1155-9.
PMID: 15475941
Multiplex ligation-dependent probe amplification (MLPA) is a recently described method for detecting gross deletions or duplications of DNA sequences, aberrations which are commonly overlooked by standard diagnostic analysis. To determine...
16.
Evans D, Eccles D, Rahman N, Young K, Bulman M, Amir E, et al.
J Med Genet
. 2004 Jun;
41(6):474-80.
PMID: 15173236
Purpose: To develop a simple scoring system for the likelihood of identifying a BRCA1 or BRCA2 mutation. Methods: DNA samples from affected subjects from 422 non-Jewish families with a history...
17.
Eccles D, Evans D
Breast
. 2004 Feb;
9(6):301-5.
PMID: 14965751
Approximately 5% of all breast cancers arise on a background of one of the high-risk breast cancer genes (hereditary breast cancer and hereditary breast and ovarian cancer). An estimated 20%...
18.
Parham D, Eccles D
Breast
. 2004 Feb;
10(4):330-2.
PMID: 14965603
This report describes a patient with Li Fraumeni Syndrome who first presented with an unusual fibroadenoma containing atypical multinucleated giant cells. These cells are thought to be fibrohistiocytic in nature...
19.
Antoniou A, Pharoah P, Narod S, Risch H, Eyfjord J, Hopper J, et al.
Am J Hum Genet
. 2003 Apr;
72(5):1117-30.
PMID: 12677558
Germline mutations in BRCA1 and BRCA2 confer high risks of breast and ovarian cancer, but the average magnitude of these risks is uncertain and may depend on the context. Estimates...
20.
Eccles D, Barker S, Pilz D, Kennedy C
J Med Genet
. 2003 Mar;
40(3):e24.
PMID: 12624153
No abstract available.