D M Bloomfield
Overview
Explore the profile of D M Bloomfield including associated specialties, affiliations and a list of published articles.
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Articles
21
Citations
417
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Recent Articles
1.
Bloomfield D
Clin Pharmacol Ther
. 2015 Feb;
97(5):444-6.
PMID: 25677192
ICH E14 mandates that a thorough QTc study (TQT) is conducted as part of the clinical drug development program to provide an accurate and precise estimate of a drug's effect...
2.
Bloomfield D
Clin Pharmacol Ther
. 2009 Mar;
85(4):365-6.
PMID: 19295536
Electrocardiograms (ECGs) in patients with Parkinson's disease are affected by artifacts related to muscle tremor. Malik et al. report methods used in QTc study in patients with Parkinson's disease that...
3.
Bloomfield D, Kost J, Ghosh K, Hreniuk D, Hickey L, Guitierrez M, et al.
Clin Pharmacol Ther
. 2009 Feb;
84(4):475-80.
PMID: 19238652
A number of issues have remained unanswered in the design of "thorough QT"(TQT) studies. In this randomized, placebo-controlled, two-period crossover study in 20 healthy subjects, replicate electrocardiograms (ECGs) were recorded...
4.
Krishna R, BERGMAN A, Jin B, Fallon M, Cote J, Van Hoydonck P, et al.
Clin Pharmacol Ther
. 2008 Jun;
84(6):679-83.
PMID: 18580870
No abstract available.
5.
Iwamoto M, Kost J, Mistry G, Wenning L, Breidinger S, Marbury T, et al.
J Clin Pharmacol
. 2008 Apr;
48(6):726-33.
PMID: 18441333
Raltegravir is a novel HIV-1 integrase inhibitor with potent in vitro activity (IC(95) = 31 nM in 50% human serum). A double-blind, randomized, placebo-controlled, double-dummy, 3-period, single-dose crossover study was...
6.
Hohnloser S, Ikeda T, Bloomfield D, Dabbous O, Cohen R
Lancet
. 2003 Jul;
362(9378):125-6.
PMID: 12867114
In a trial of prophylactic implantation of a defibrillator, a mortality benefit was seen among patients with previous myocardial infarction and a left-ventricular ejection fraction of 0.30 or less. We...
7.
Rosenwinkel E, Bloomfield D, Arwady M, Goldsmith R
Cardiol Clin
. 2001 Sep;
19(3):369-87.
PMID: 11570111
Autonomic nervous system activity contributes to the regulation of cardiac output during rest, exercise, and cardiovascular disease. Measurement of HRV has been particularly useful in assessing parasympathetic activity, while its...
8.
Bloomfield D, Magnano A, BIGGER Jr J, Rivadeneira H, Parides M, Steinman R
Am J Physiol Heart Circ Physiol
. 2001 Feb;
280(3):H1145-50.
PMID: 11179058
R-R interval variability (RR variability) is increasingly being used as an index of autonomic activity. High-frequency (HF) power reflects vagal modulation of the sinus node. Since vagal modulation occurs at...
9.
Gold M, Bloomfield D, Anderson K, Wilber D, Groh W, Estes 3rd N, et al.
J Am Coll Cardiol
. 2000 Dec;
36(7):2247-53.
PMID: 11127468
Objectives: The goal of this study was to compare T-wave alternans (TWA), signal-averaged electrocardiography (SAECG) and programmed ventricular stimulation (EPS) for arrhythmia risk stratification in patients undergoing electrophysiology study. Background:...
10.
Maurer M, Karmally W, Rivadeneira H, Parides M, Bloomfield D
Ann Intern Med
. 2000 Oct;
133(7):533-6.
PMID: 11015166
Background: Syncope and falls are common in elderly persons and often result from the interaction of multiple clinical abnormalities. Both orthostatic hypotension and postprandial hypotension increase in prevalence with age....