D L Greiner
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Explore the profile of D L Greiner including associated specialties, affiliations and a list of published articles.
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154
Citations
2937
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Recent Articles
1.
Kenney L, Shultz L, Greiner D, Brehm M
Am J Transplant
. 2015 Nov;
16(2):389-97.
PMID: 26588186
Our understanding of the molecular pathways that control immune responses, particularly immunomodulatory molecules that control the extent and duration of an immune response, have led to new approaches in the...
2.
Samanta S, Sun H, Goel H, Pursell B, Chang C, Khan A, et al.
Oncogene
. 2015 May;
35(9):1111-21.
PMID: 25982283
IMP3 (insulin-like growth factor-2 mRNA binding protein 3) is an oncofetal protein whose expression is prognostic for poor outcome in several cancers. Although IMP3 is expressed preferentially in triple-negative breast...
3.
Wilson E, Bial J, Tarlow B, Bial G, Jensen B, Greiner D, et al.
Stem Cell Res
. 2014 Oct;
13(3 Pt A):404-12.
PMID: 25310256
Preclinical research in animals often fails to adequately predict the outcomes observed in human patients. Chimeric animals bearing individual human tissues have been developed to provide improved models of human-specific...
4.
Babad J, Mukherjee G, Follenzi A, Ali R, Roep B, Shultz L, et al.
Clin Exp Immunol
. 2014 Oct;
179(3):398-413.
PMID: 25302633
Several β cell antigens recognized by T cells in the non-obese diabetic (NOD) mouse model of type 1 diabetes (T1D) are also T cell targets in the human disease. While...
5.
McNeer N, Schleifman E, Cuthbert A, Brehm M, Jackson A, Cheng C, et al.
Gene Ther
. 2012 Oct;
20(6):658-69.
PMID: 23076379
In vivo delivery is a major barrier to the use of molecular tools for gene modification. Here we demonstrate site-specific gene editing of human cells in vivo in hematopoietic stem...
6.
Brehm M, Daniels K, Priyadharshini B, Thornley T, Greiner D, Rossini A, et al.
Am J Transplant
. 2010 Jul;
10(8):1738-48.
PMID: 20659086
Viral infections have been associated with the rejection of transplanted allografts in humans and mice, and the induction of tolerance to allogeneic tissues in mice is abrogated by an ongoing...
7.
Ishigaki S, Fonseca S, Oslowski C, Jurczyk A, Shearstone J, Zhu L, et al.
Cell Death Differ
. 2009 Nov;
17(5):774-86.
PMID: 19911006
Endoplasmic reticulum (ER) stress-mediated cell death has an important role in the pathogenesis of chronic diseases, including diabetes and neurodegeneration. Although proapoptotic programs activated by ER stress have been extensively...
8.
King M, Covassin L, Brehm M, Racki W, Pearson T, Leif J, et al.
Clin Exp Immunol
. 2009 Aug;
157(1):104-18.
PMID: 19659776
Immunodeficient non-obese diabetic (NOD)-severe combined immune-deficient (scid) mice bearing a targeted mutation in the gene encoding the interleukin (IL)-2 receptor gamma chain gene (IL2rgamma(null)) engraft readily with human peripheral blood...
9.
Pearson T, Shultz L, Miller D, King M, Laning J, Fodor W, et al.
Clin Exp Immunol
. 2008 Sep;
154(2):270-84.
PMID: 18785974
Immunodeficient hosts engrafted with human lymphohaematopoietic cells hold great promise as a preclinical bridge for understanding human haematopoiesis and immunity. We now describe a new immunodeficient radioresistant non-obese diabetic mice...
10.
Pearson T, Shultz L, Lief J, Burzenski L, Gott B, Chase T, et al.
Diabetologia
. 2008 Jun;
51(8):1449-56.
PMID: 18563383
Aims/hypothesis: To develop and validate a new immunodeficient mouse strain that spontaneously develops a non-autoimmune hyperglycaemia to serve as a diabetic host for human islets and human beta stem and...