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D J Conklin

Explore the profile of D J Conklin including associated specialties, affiliations and a list of published articles. Areas
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Articles 35
Citations 198
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Recent Articles
1.
Jin L, Xie Z, Lorkiewicz P, Srivastava S, Bhatnagar A, Conklin D
Am J Physiol Heart Circ Physiol . 2023 Oct; 325(6):H1446-H1460. PMID: 37889254
Epidemiological evidence shows that residential proximity to greenspaces is associated with lower risk of all-cause and cardiovascular mortality; however, the mechanism(s) underlying this link remains unclear. Plants emit biogenic volatile...
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Jin L, Lorkiewicz P, Xie Z, Bhatnagar A, Srivastava S, Conklin D
Toxicol Appl Pharmacol . 2021 Jul; 426:115647. PMID: 34271065
Acrolein, an electrophilic α,β-unsaturated aldehyde, is present in foods and beverages, and is a product of incomplete combustion, and thus, reaches high ppm levels in tobacco smoke and structural fires....
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Jin L, Jagatheesan G, Lynch J, Guo L, Conklin D
Toxicol Appl Pharmacol . 2020 Apr; 398:115012. PMID: 32320793
Introduction: Crotonaldehyde (CR) is an electrophilic α,β-unsaturated aldehyde present in foods and beverages and is a minor metabolite of 1,3-butadiene. CR is a product of incomplete combustion, and is at...
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Jin L, Jagatheesan G, Guo L, Nystoriak M, Malovichko M, Lorkiewicz P, et al.
Front Physiol . 2019 Apr; 10:277. PMID: 30984013
Formaldehyde (FA), the smallest aldehyde, is generated endogenously, and is widespread in the environment in foods, beverages and as a gas phase product of incomplete combustion. The main metabolite of...
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Wan Y, Datta S, Conklin D, Kong M
J Stat Comput Simul . 2015 Sep; 85(9):1902-1916. PMID: 26412909
The statistical methods for variable selection and prediction could be challenging when missing covariates exist. Although multiple imputation (MI) is a universally accepted technique for solving missing data problem, how...
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Makia N, Amunom I, Falkner K, Conklin D, Surapureddi S, Goldstein J, et al.
Mol Pharmacol . 2012 Jun; 82(4):601-13. PMID: 22740640
Previously we demonstrated that aldehyde dehydrogenase (ALDH) 1a1 is the major ALDH expressed in mouse liver and is an effective catalyst in metabolism of lipid aldehydes. Quantitative real-time polymerase chain...
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Conklin D, Bhatnagar A, Cowley H, Johnson G, Wiechmann R, Sayre L, et al.
Toxicol Appl Pharmacol . 2006 Nov; 217(3):277-88. PMID: 17095030
Increased risk of vasospasm, a spontaneous hyperconstriction, is associated with atherosclerosis, cigarette smoking, and hypertension-all conditions involving oxidative stress, lipid peroxidation, and inflammation. To test the role of the lipid...
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Awe S, Adeagbo A, DSouza S, Bhatnagar A, Conklin D
Toxicol Appl Pharmacol . 2006 Oct; 217(3):266-76. PMID: 17069868
Acrolein is generated endogenously during lipid peroxidation and inflammation and is an environmental pollutant. Protein adducts of acrolein are detected in atherosclerotic plaques and neurons of patients with Alzheimer's disease....
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Conklin D, Cowley H, Wiechmann R, Johnson G, Trent M, Boor P
Am J Physiol Heart Circ Physiol . 2004 Jan; 286(2):H667-76. PMID: 14715500
It is hypothesized that methylamine (MA) and semicarbazide-sensitive amine oxidase (SSAO) activity are involved in the cardiovascular complications in human diabetics. To test this, we 1) determined the acute vasoactive...