D G Sixsmith
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Explore the profile of D G Sixsmith including associated specialties, affiliations and a list of published articles.
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18
Citations
181
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Recent Articles
1.
WATKINS W, Chulay J, Sixsmith D, SPENCER H, Howells R
J Pharm Pharmacol
. 1987 Apr;
39(4):261-5.
PMID: 2884288
Pharmacokinetic parameters for cycloguanil and chlorcycloguanil, the active metabolites of proguanil (Paludrine] and chlorproguanil (Lapudrine) have been measured in a bioassay which assesses the in-vitro growth inhibition of a cycloguanil-...
2.
SPENCER H, WATKINS W, Sixsmith D, Koech D
Trans R Soc Trop Med Hyg
. 1986 Jan;
80(2):201-3.
PMID: 3538522
The response of Plasmodium falciparum isolates to dihydrofolate reductase inhibitors (DHFRI) was examined in Malindi, Kenya. All 20 infected children treated with pyrimethamine/sulphadoxine responded. In contrast, after treatment with pyrimethamine,...
3.
SPENCER H, Sixsmith D, WATKINS W, Koech D, Chulay J
Trans R Soc Trop Med Hyg
. 1985 Jan;
79(1):116-8.
PMID: 3887676
No abstract available.
4.
WATKINS W, Sixsmith D, Chulay J, SPENCER H
Mol Biochem Parasitol
. 1985 Jan;
14(1):55-61.
PMID: 3885030
The activity of pyrimethamine and sulfadoxine against two strains of Plasmodium falciparum has been studied in vitro by a radioisotopic technique. Low level antagonism of pyrimethamine resulted from the inclusion...
5.
Sixsmith D, WATKINS W, Chulay J, SPENCER H
Am J Trop Med Hyg
. 1984 Sep;
33(5):772-6.
PMID: 6385738
Three tetrahydrofolate dehydrogenase (dihydrofolate reductase = EC 1.5.1.3) inhibitors were tested for antimalarial activity against Plasmodium falciparum, using an in vitro radioisotopic technique. Activity of each drug was tested in...
6.
WATKINS W, Sixsmith D, Chulay J
Ann Trop Med Parasitol
. 1984 Jun;
78(3):273-8.
PMID: 6385887
Using an in vitro radioisotopic method, the activity was measured of proguanil, its metabolites cycloguanil and p-chlorophenylbiguanide (PBG), pyrimethamine, and chloroquine against seven Kenyan and three South East Asian strains...
7.
Chulay J, WATKINS W, Sixsmith D
Am J Trop Med Hyg
. 1984 May;
33(3):325-30.
PMID: 6375404
Two strains of Plasmodium falciparum were tested in vitro for sensitivity to the dihydrofolate reductase inhibitor pyrimethamine, the p-aminobenzoic acid (PABA) analogue sulfadoxine, and combinations of both drugs. One strain...
8.
SPENCER H, Oloo A, WATKINS W, Sixsmith D, Churchill F, Koech D
Lancet
. 1984 Apr;
1(8383):956-7.
PMID: 6143883
No abstract available.
9.
WATKINS W, Sixsmith D, SPENCER H, Boriga D, Kariuki D, Kipingor T, et al.
Lancet
. 1984 Feb;
1(8373):357-9.
PMID: 6141423
Studies were conducted in Malindi, Kenya, to assess the response of Plasmodium falciparum to chloroquine and amodiaquine in vivo (by an extended 14-day test) and in vitro (with the Rieckmann...
10.
SPENCER H, WATKINS W, Sixsmith D, Koech D, Chulay J
Bull World Health Organ
. 1984 Jan;
62(4):615-21.
PMID: 6386209
A useful in vitro method for field evaluation of Plasmodium falciparum sensitivity to pyrimethamine/sulfadoxine is described. Thirty-five Kenyan schoolchildren infected with P. falciparum were treated with this drug combination and...