D Forrest
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Explore the profile of D Forrest including associated specialties, affiliations and a list of published articles.
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93
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2065
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Recent Articles
11.
Suzuki H, Zhang X, Forrest D, Willingham M, Cheng S
Mol Endocrinol
. 2003 Feb;
17(5):895-907.
PMID: 12576488
Mutations in the thyroid hormone receptor (TR) beta gene result in resistance to thyroid hormone (RTH), characterized by reduced sensitivity of tissues to thyroid hormone. To understand which physiological TR...
12.
Rusch A, Ng L, Goodyear R, Oliver D, Lisoukov I, Vennstrom B, et al.
J Neurosci
. 2001 Dec;
21(24):9792-800.
PMID: 11739587
The deafness caused by early onset hypothyroidism indicates that thyroid hormone is essential for the development of hearing. We investigated the underlying roles of the TRalpha1 and TRbeta thyroid hormone...
13.
Salto C, Kindblom J, Johansson C, Wang Z, Gullberg H, Nordstrom K, et al.
Mol Endocrinol
. 2001 Dec;
15(12):2115-28.
PMID: 11731613
Thyroid hormone governs a diverse repertoire of physiological functions through receptors encoded in the receptor genes alpha and beta, which each generate variant proteins. In mammals, the alpha gene generates,...
14.
TRs have common and isoform-specific functions in regulation of the cardiac myosin heavy chain genes
Mansen A, Yu F, Forrest D, Larsson L, Vennstrom B
Mol Endocrinol
. 2001 Dec;
15(12):2106-14.
PMID: 11731612
TRalpha1 and TRbeta mediate the regulatory effects of T3 and have profound effects on the cardiovascular system. We have analyzed the expression of the cardiac myosin heavy chain (MyHC) genes...
15.
Ng L, Rusch A, Amma L, Nordstrom K, Erway L, Vennstrom B, et al.
Hum Mol Genet
. 2001 Dec;
10(23):2701-8.
PMID: 11726557
Deletion of thyroid hormone receptor beta (TR beta), a ligand-dependent transcription factor encoded by the Thrb gene, causes deafness and thyroid hyperactivity in Thrb-null (Thrb(tm1/tm1)) mice and in a recessive...
16.
Kindblom J, Gothe S, Forrest D, Tornell J, Vennstrom B, Ohlsson C
J Endocrinol
. 2001 Sep;
171(1):15-22.
PMID: 11572786
Thyroid hormone receptor alpha 1, beta 1 and beta 2-deficient mice (TR alpha 1-/-beta-/- mice) demonstrate growth retardation and defective ossification in the epiphyses associated with an inhibition of the...
17.
Ng L, Pedraza P, Faris J, Vennstrom B, Curran T, Morreale de Escobar G, et al.
Neuroreport
. 2001 Aug;
12(11):2359-62.
PMID: 11496110
As early-onset hypothyroidism produces audiogenic seizure susceptibility (AGS) in rodents, the role of TR alpha 1 and TR beta thyroid hormone receptors in AGS was investigated. AGS occurs in mice...
18.
Billon N, Tokumoto Y, Forrest D, Raff M
Dev Biol
. 2001 Jun;
235(1):110-20.
PMID: 11412031
The timing of oligodendrocyte differentiation is thought to depend on both intracellular mechanisms and extracellular signals. Thyroid hormone (TH) helps control this timing both in vitro and in vivo, but...
19.
Amma L, Campos-Barros A, Wang Z, Vennstrom B, Forrest D
Mol Endocrinol
. 2001 Feb;
15(3):467-75.
PMID: 11222747
Type 1 deiodinase (D1) metabolizes different forms of thyroid hormones to control levels of T3, the active ligand for thyroid hormone receptors (TR). The D1 gene is itself T3-inducible and...
20.
Ng L, Hurley J, Dierks B, Srinivas M, Salto C, Vennstrom B, et al.
Nat Genet
. 2001 Jan;
27(1):94-8.
PMID: 11138006
Color vision is facilitated by distinct populations of cone photoreceptors in the retina. In rodents, cones expressing different opsin photopigments are sensitive to middle (M, 'green') and short (S, 'blue')...