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D E McFadden

Explore the profile of D E McFadden including associated specialties, affiliations and a list of published articles. Areas
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Articles 28
Citations 543
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Recent Articles
1.
Filges I, Manokhina I, Penaherrera M, McFadden D, Louie K, Nosova E, et al.
Mol Hum Reprod . 2014 Dec; 21(4):339-46. PMID: 25504873
Triploidy is a relatively common cause of miscarriage; however, recurrent triploidy has rarely been reported. A healthy 34-year-old woman was ascertained because of 18 consecutive miscarriages with triploidy found in...
2.
Blair J, Langlois S, McFadden D, Robinson W
Placenta . 2014 Jan; 35(3):216-22. PMID: 24462402
Introduction: Maternal preeclampsia is associated with altered placental development in the first trimester of pregnancy. Confined placental trisomy 16 mosaicism (CPM16) is a genetic abnormality of the placenta that is...
3.
Gover A, Chau V, Miller S, Brant R, McFadden D, Poskitt K, et al.
J Perinatol . 2013 Apr; 33(8):647-51. PMID: 23558431
Objective: To examine whether early inflammation is related to cortisol levels at 18 months corrected age (CA) in children born very preterm. Study Design: Infants born ≤ 32 weeks of...
4.
Manokhina I, Hanna C, Stephenson M, McFadden D, Robinson W
Mol Hum Reprod . 2013 Mar; 19(8):539-44. PMID: 23515668
Maternal effect genes control early events of embryogenesis. Maternal homozygous and compound mutations in two such genes, NLRP7 and c6orf221, have been detected in the majority of women experiencing recurrent...
5.
Bourque D, Penaherrera M, Yuen R, Van Allen M, McFadden D, Robinson W
Clin Genet . 2010 May; 79(2):169-75. PMID: 20507345
An imbalance of imprinted gene expression within 11p15.5 is observed in Beckwith-Wiedemann syndrome (BWS), as well as in a variety of placental abnormalities including complete hydatidiform mole (CHM), placental mesenchymal...
6.
Robinson W, Slee J, Smith N, Murch A, Watson S, Lam W, et al.
Am J Med Genet A . 2007 Jun; 143A(15):1752-9. PMID: 17593542
Placentae with mesenchymal dysplasia (PMD) are typically larger than average and show cystic areas on ultrasonography. Fetal outcomes are variable and are often associated with growth restriction. However, enigmatically, some...
7.
Hirschfeld A, Jiang R, Robinson W, McFadden D, Turvey S
Hum Reprod . 2006 Sep; 22(2):440-3. PMID: 16982657
Background: Lipopolysaccharide (LPS or endotoxin) exposure resulting from microbial invasion of the endometrium disturbs the Th1/Th2 balance at the feto-maternal interface and has been linked to the risk of idiopathic...
8.
McFadden D, Robinson W
J Med Genet . 2005 Oct; 43(7):609-12. PMID: 16236813
The phenotypes of triploid fetuses and placentae are now well established and known to correlate with parental origin of the extra haploid set of chromosomes. In fetuses, it is not...
9.
Kaiser-Rogers K, McFadden D, Livasy C, Dansereau J, Jiang R, Knops J, et al.
J Med Genet . 2005 May; 43(2):187-92. PMID: 15908568
Background: Placental mesenchymal dysplasia (PMD) is a distinct syndrome of unknown aetiology that is associated with significant fetal morbidity and mortality. Intrauterine growth restriction is common, yet, paradoxically, many of...
10.
Robinson W, McFadden D, Stephenson M
Am J Hum Genet . 2001 Oct; 69(6):1245-54. PMID: 11675616
Recurrent miscarriage due to sporadic chromosomal abnormalities may simply be a consequence of the dramatic increase of trisomic conceptions with increased maternal age. However, it is also possible that some...