D D Schoepp
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Explore the profile of D D Schoepp including associated specialties, affiliations and a list of published articles.
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140
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3431
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Recent Articles
1.
Witkin J, Monn J, Schoepp D, Li X, Overshiner C, Mitchell S, et al.
J Pharmacol Exp Ther
. 2016 May;
358(1):71-82.
PMID: 27189960
Ketamine is a rapidly acting antidepressant in patients with treatment-resistant depression (TRD). Although the mechanisms underlying these effects are not fully established, inquiry to date has focused on the triggering...
2.
Nicoletti F, Bockaert J, Collingridge G, Conn P, Ferraguti F, Schoepp D, et al.
Neuropharmacology
. 2010 Nov;
60(7-8):1017-41.
PMID: 21036182
Metabotropic glutamate (mGlu) receptors were discovered in the mid 1980s and originally described as glutamate receptors coupled to polyphosphoinositide hydrolysis. Almost 6500 articles have been published since then, and subtype-selective...
3.
Schoepp D, Johnson B
Neurochem Int
. 2010 May;
18(3):411-7.
PMID: 20504719
In previous work we found that 2-amino-3-phosphonopropionic acid, the ?-phosphono-substituted analog of aspartic acid, is a selective in vitro inhibitor of the excitatory amino acid agonist [ibotenate, quisqualate, trans(+/-)-1-amino-1,3-cyclopentanedicarboxylic acid...
4.
Schoepp D
Neurochem Int
. 2010 May;
15(2):131-6.
PMID: 20504474
Stimulation of phosphoinositide hydrolysis by excitatory amino acid agonists, but not cholinoceptor or adrenoceptor agonists was greater in hippocampal tissue from neonatal rats when compared to mature rats. Ibotenate (10(?3)...
5.
Schoepp D, Bailly D
Neurochem Int
. 2010 May;
11(2):149-54.
PMID: 20501155
In this study, slices of rat anterior pituitary were prelabeled with [(3)H]myo-inositol and the ability of angiotensins II and III to stimulate [(3)H]phosphoinositide hydrolysis was characterized. When using tissue derived...
6.
Linden A, Johnson B, Trokovic N, Korpi E, Schoepp D
Neuropharmacology
. 2009 May;
57(2):172-82.
PMID: 19477188
LY341495 is a metabotropic glutamate receptor (mGluR) antagonist showing selectivity to mGluR2/3 but having measurable antagonist efficacy across all mGluR subtypes at 10-1000 fold higher concentrations. In vivo in rodents...
7.
Nie Y, Schoepp D, Klaunig J, Yard M, Lahiri D, Kubek M
Brain Res
. 2005 Aug;
1054(1):45-54.
PMID: 16055093
Excess excitatory amino acid release is involved in pathways associated with seizures and neurodegeneration. Thyrotropin-releasing hormone (TRH; protirelin), a brain-derived tripeptide, has shown efficacy in the treatment of such disorders,...
8.
Linden A, Bergeron M, Schoepp D
Neuropharmacology
. 2005 Jul;
49 Suppl 1:120-34.
PMID: 16023151
LY341495 and LY354740 are potent and selective antagonist and agonist, respectively, for Group II metabotropic glutamate (mGlu2/3) receptors. Here we demonstrate that LY341495 (3 mg/kg) significantly increased c-Fos expression in...
9.
Linden A, Shannon H, Baez M, Yu J, Koester A, Schoepp D
Psychopharmacology (Berl)
. 2004 Dec;
179(1):284-91.
PMID: 15619115
Rationale: (1S,2S,5R,6S)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (LY354740) is a potent and selective agonist for group II metabotropic glutamate (mGlu2 and mGlu3) receptors, with anxiolytic-like activity in animal and human models, and efficacy in...
10.
Coplan J, Mathew S, Smith E, Trost R, Scharf B, Martinez J, et al.
CNS Spectr
. 2004 Dec;
6(7):607-12, 617.
PMID: 15573025
The search for novel anxiolytics and antidepressants has focused on compounds with the potential to reduce excessive hypothalamic-pituitary-adrenal (HPA) axis activity. L-glutamate, an excitatory neurotransmitter ubiquitously present within the central...