D Alastair Smith
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Explore the profile of D Alastair Smith including associated specialties, affiliations and a list of published articles.
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33
Citations
783
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Recent Articles
1.
Saunders J, Young L, Mahood R, Jackson M, Revill C, Foster R, et al.
Nat Chem Biol
. 2015 Dec;
12(2):94-101.
PMID: 26656088
Protein aggregation underlies an array of human diseases, yet only one small-molecule therapeutic targeting this process has been successfully developed to date. Here, we introduce an in vivo system, based...
2.
Gibson C, Smith D, Roberts C
Nanotechnology
. 2011 Jul;
16(2):234-8.
PMID: 21727428
We present a comparison of three different methods to calibrate the spring constant of two different types of silicon beam shaped atomic force microscope (AFM) cantilevers to determine each method's...
3.
Noronha M, Gerbelova H, Faria T, Lund D, Smith D, Santos H, et al.
J Phys Chem B
. 2010 Jul;
114(30):9912-9.
PMID: 20666531
Thermal folding/unfolding kinetics of wild-type ubiquitin (wt-UBQ) was studied in a wide time range, from microseconds to seconds, by combining rapid-mixing T-jump and laser T-jump with fluorescence detection (MTJ-F and...
4.
Pugh S, Gell C, Smith D, Radford S, Brockwell D
J Mol Biol
. 2010 Mar;
398(1):132-45.
PMID: 20211187
Under appropriate conditions, the four-helical Im7 (immunity protein 7) folds from an ensemble of unfolded conformers to a highly compact native state via an on-pathway intermediate. Here, we investigate the...
5.
Harris A, Garg M, Yang X, Fisher S, Kirkham J, Smith D, et al.
Head Neck Oncol
. 2009 Oct;
1:38.
PMID: 19863815
Raman spectroscopy could offer non-invasive, rapid and an objective nature to cancer diagnostics. However, much work in this field has focused on resolving differences between cancerous and non-cancerous tissues, and...
6.
Kawakami M, Taniguchi Y, Hiratsuka Y, Shimoike M, Smith D
Langmuir
. 2009 Sep;
26(2):1002-7.
PMID: 19785459
In single molecule force measurements with soft atomic force microscope (AFM) cantilevers, the force sensitivity is limited by the Brownian motion of the cantilever. When a cantilever is close to...
7.
Harris A, Lungari A, Needham C, Smith S, Lones M, Fisher S, et al.
Head Neck Oncol
. 2009 Sep;
1:34.
PMID: 19761601
Cancer poses a massive health burden with incidence rates expected to double globally over the next decade. In the United Kingdom screening programmes exists for cervical, breast, and colorectal cancer....
8.
Friel C, Smith D, Vendruscolo M, Gsponer J, Radford S
Nat Struct Mol Biol
. 2009 Mar;
16(3):318-24.
PMID: 19252485
Many proteins reach their native state through pathways involving the presence of folding intermediates. It is not clear whether this type of folding landscape results from insufficient evolutionary pressure to...
9.
Khatri B, Byrne K, Kawakami M, Brockwell D, Smith D, Radford S, et al.
Faraday Discuss
. 2008 Dec;
139:35-51.
PMID: 19048989
Experiments that measure the viscoelasticity of single molecules from the Brownian fluctuations of an atomic force microscope (AFM) have provided a new window onto their internal dynamics in an underlying...
10.
Tang H, Yang X, Kirkham J, Smith D
Appl Spectrosc
. 2008 Oct;
62(10):1060-9.
PMID: 18926013
By using near-infrared surface-enhanced Raman scattering (SERS) with 60 nm gold nanoparticles (Au-NPs) to probe the chemical composition inside single human osteosarcoma cells we have shown that the SERS intensity...