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D A van Heel

Explore the profile of D A van Heel including associated specialties, affiliations and a list of published articles. Areas
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Articles 26
Citations 578
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Recent Articles
1.
Lam B, Williamson A, Finer S, Day F, Tadross J, Goncalves Soares A, et al.
Nature . 2021 Nov; 599(7885):436-441. PMID: 34732894
The state of somatic energy stores in metazoans is communicated to the brain, which regulates key aspects of behaviour, growth, nutrient partitioning and development. The central melanocortin system acts through...
2.
OCallaghan N, Adams K, van Heel D, Cavanaugh J
Scand J Gastroenterol . 2017 Apr; 38(5):533-534. PMID: 28443765
Background: It is now well established that susceptibility to inflammatory bowel disease is in part genetic, with one localization on chromosome 6 (IBD3) having been replicated in a number of...
3.
Garner C, Murray J, Ding Y, Tien Z, van Heel D, Neuhausen S
Hum Mol Genet . 2009 Aug; 18(21):4219-25. PMID: 19648293
Celiac disease is a common disease with a prevalence of approximately 1%. A recent genome-wide association study (GWAS) and follow-up study identified eight loci significantly associated with celiac disease risk....
4.
Trynka G, Zhernakova A, Romanos J, Franke L, Hunt K, Turner G, et al.
Gut . 2009 Feb; 58(8):1078-83. PMID: 19240061
Objective: Our previous coeliac disease genome-wide association study (GWAS) implicated risk variants in the human leucocyte antigen (HLA) region and eight novel risk regions. To identify more coeliac disease loci,...
5.
Dubois P, van Heel D
Clin Exp Immunol . 2008 Aug; 153(2):162-73. PMID: 18713140
Recent advances in immunological and genetic research in coeliac disease provide new and complementary insights into the immune response driving this chronic intestinal inflammatory disorder. Both approaches confirm the central...
6.
Adamovic S, Amundsen S, Lie B, Gudjonsdottir A, Ascher H, Ek J, et al.
Genes Immun . 2008 Apr; 9(4):364-7. PMID: 18418394
The first genome-wide association study performed in a UK coeliac disease (CD) case-control cohort revealed association with a linkage disequilibrium block containing the KIAA1109/Tenr/IL2/IL21 genes. Also recently, an association with...
7.
Wapenaar M, Monsuur A, van Bodegraven A, Weersma R, Bevova M, Linskens R, et al.
Gut . 2007 Nov; 57(4):463-7. PMID: 17989107
Background: Coeliac disease (gluten-sensitive enteropathy; GSE) and inflammatory bowel disease (IBD) are common gastrointestinal disorders. Both display enhanced intestinal permeability, initiated by gluten exposure (GSE) or bacterial interactions (IBD). Previous...
8.
van Heel D, West J
Gut . 2006 Jun; 55(7):1037-46. PMID: 16766754
No abstract available.
9.
van Heel D
Gut . 2006 Mar; 55(4):444-5. PMID: 16531523
No abstract available.
10.
Hunt K, Monsuur A, McArdle W, Kumar P, Travis S, Walters J, et al.
Gut . 2006 Jan; 55(7):969-72. PMID: 16423886
Background And Aims: Development of coeliac disease involves an interaction between environmental factors (especially dietary wheat, rye, and barley antigens) and genetic factors (there is strong inherited disease susceptibility). The...