D A Dart
Overview
Explore the profile of D A Dart including associated specialties, affiliations and a list of published articles.
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Articles
7
Citations
238
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0
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Recent Articles
1.
Dart D, Ashelford K, Jiang W
Endocr Connect
. 2019 Nov;
9(1):9-19.
PMID: 31778359
Advanced prostate cancer is often treated with AR antagonists which target the androgen receptor (AR) on which the growth of the tumour depends. Prostate cancer often develops AR-antagonist resistance via...
2.
Koushyar S, Economides G, Zaat S, Jiang W, Bevan C, Dart D
Oncogenesis
. 2017 May;
6(5):e333.
PMID: 28504694
Prohibitin (PHB) is a tumour suppressor molecule with pleiotropic activities across several cellular compartments including mitochondria, cell membrane and the nucleus. PHB and the steroid-activated androgen receptor (AR) have an...
3.
Sita-Lumsden A, Dart D, Waxman J, Bevan C
Br J Cancer
. 2013 May;
108(10):1925-30.
PMID: 23632485
Since they were first described in the 1990s, circulating microRNAs (miRNAs) have provided an active and rapidly evolving area of current research that has the potential to transform cancer diagnostics...
4.
Dart D, Brooke G, Sita-Lumsden A, Waxman J, Bevan C
Oncogene
. 2011 Dec;
31(43):4588-98.
PMID: 22179832
Prostate cancers (PCs), initially responsive to anti-androgen therapies, often advance to a hormone-refractory 'castrate-resistant' PC (CRPC) stage. However, the androgen receptor (AR) pathway remains active and key for cell growth...
5.
Powell S, Brooke G, Whitaker H, Reebye V, Gamble S, Chotai D, et al.
Biochem Soc Trans
. 2006 Nov;
34(Pt 6):1124-7.
PMID: 17073766
Anti-androgens used in prostate cancer therapy inhibit AR (androgen receptor) activity via largely unknown mechanisms. Although initially successful in most cases, they eventually fail and the disease progresses. We need...
6.
Gamble S, Chotai D, Odontiadis M, Dart D, Brooke G, Powell S, et al.
Oncogene
. 2006 Sep;
26(12):1757-68.
PMID: 16964284
Prohibitin (PHB) is a cell cycle regulatory protein, known to repress E2F1-mediated gene activation via recruitment of transcriptional regulatory factors such as retinoblastoma and histone deacetylase 1 (HDAC1). We previously...
7.
Adams K, Medhurst A, Dart D, Lakin N
Oncogene
. 2006 Feb;
25(28):3894-904.
PMID: 16474843
ATM and ATR are two related kinases essential for signalling DNA damage. Although ATM is thought to be the principle kinase responsible for signalling ionising radiation (IR)-induced DNA damage, ATR...