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Cynthie Wong

Explore the profile of Cynthie Wong including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 7
Citations 251
Followers 0
Related Specialties
Biochemistry
Oncology
Molecular Biology
Top 10 Co-Authors
Shiuan Chen
Mei Wang
Li-Yu Hsin
Yate-Ching Yuan
David Smith
Kaladhar Reddy
Dujin Zhou
Su-Chiung Fang
Raffi V Aroian
Edward Platzer
Published In
J Steroid Biochem Mol Biol
Proc Natl Acad Sci U S A
Arterioscler Thromb Vasc Biol
Breast Cancer Res Treat
Cancer Res
Affiliations
Soon will be listed here.
Recent Articles
1.
AroER tri-screen is a biologically relevant assay for endocrine disrupting chemicals modulating the activity of aromatase and/or the estrogen receptor
Chen S, Zhou D, Hsin L, Kanaya N, Wong C, Yip R, et al.
Toxicol Sci . 2014 Feb; 139(1):198-209. PMID: 24496634
Endocrine disrupting chemicals (EDCs) interfere with the biosynthesis, metabolism, and functions of steroid hormones, including estrogens and androgens. Aromatase enzyme converts androgen to estrogen. Thus, EDCs against aromatase significantly impact...
2.
AKT-aro and HER2-aro, models for de novo resistance to aromatase inhibitors; molecular characterization and inhibitor response studies
Wong C, Wang X, Smith D, Reddy K, Chen S
Breast Cancer Res Treat . 2012 Jun; 134(2):671-81. PMID: 22706627
Aromatase inhibitors (AI) are currently the first line therapy for estrogen receptor (ER)-positive postmenopausal women. De novo AI resistance is when a patient intrinsically does not respond to an AI...
3.
The development, application and limitations of breast cancer cell lines to study tamoxifen and aromatase inhibitor resistance
Wong C, Chen S
J Steroid Biochem Mol Biol . 2012 Jan; 131(3-5):83-92. PMID: 22265958
Estrogen plays important roles in hormone receptor-positive breast cancer. Endocrine therapies, such as the antiestrogen tamoxifen, antagonize the binding of estrogen to estrogen receptor (ER), whereas aromatase inhibitors (AIs) directly...
4.
Growth factor signaling enhances aromatase activity of breast cancer cells via post-transcriptional mechanisms
Su B, Wong C, Hong Y, Chen S
J Steroid Biochem Mol Biol . 2010 Nov; 123(3-5):101-8. PMID: 21112394
It has been demonstrated that growth factors produced by breast cancer cells stimulate aromatase expression in both breast cancer and adjacent adipose fibroblasts and stromal cells. However, whether these growth...
5.
Heat shock protein 90 inhibitors: new mode of therapy to overcome endocrine resistance
Wong C, Chen S
Cancer Res . 2009 Oct; 69(22):8670-7. PMID: 19861537
Aromatase inhibitors are important drugs to treat estrogen receptor alpha (ERalpha)-positive postmenopausal breast cancer patients. However, development of resistance to aromatase inhibitors has been observed. We examined whether the heat...
6.
Cooperation of SRC-1 and p300 with NF-kappaB and CREB in angiotensin II-induced IL-6 expression in vascular smooth muscle cells
Sahar S, Reddy M, Wong C, Meng L, Wang M, Natarajan R
Arterioscler Thromb Vasc Biol . 2007 May; 27(7):1528-34. PMID: 17495236
Objective: The purpose of this study was to evaluate the role of coactivator histone acetyltransferases (HATs) p300 and SRC-1 in angiotensin II (Ang II)-induced interleukin-6 (IL-6) gene expression in vascular...
7.
Bacillus thuringiensis crystal proteins that target nematodes
Wei J, Hale K, Carta L, Platzer E, Wong C, Fang S, et al.
Proc Natl Acad Sci U S A . 2003 Feb; 100(5):2760-5. PMID: 12598644
Bacillus thuringiensis (Bt) crystal proteins are pore-forming toxins used as insecticides around the world. Previously, the extent to which these proteins might also target the invertebrate phylum Nematoda has been...