Cynthia Linares
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Explore the profile of Cynthia Linares including associated specialties, affiliations and a list of published articles.
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11
Citations
703
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Recent Articles
1.
Liu C, Wang N, Chen Y, Inoue Y, Shue F, Ren Y, et al.
Nat Immunol
. 2023 Oct;
24(11):1854-1866.
PMID: 37857825
Microglial involvement in Alzheimer's disease (AD) pathology has emerged as a risk-determining pathogenic event. While apolipoprotein E (APOE) is known to modify AD risk, it remains unclear how microglial apoE...
2.
Meneses A, Koga S, Li Z, OLeary J, Li F, Chen K, et al.
Ann Neurol
. 2022 Dec;
93(4):830-843.
PMID: 36546684
Objective: Recent evidence supports a link between increased TDP-43 burden and the presence of an APOE4 gene allele in Alzheimer's disease (AD); however, it is difficult to conclude the direct...
3.
Zhao N, Qiao W, Li F, Ren Y, Zheng J, Martens Y, et al.
J Exp Med
. 2022 Sep;
219(12).
PMID: 36107206
TREM2 is exclusively expressed by microglia in the brain and is strongly linked to the risk for Alzheimer's disease (AD). As microglial responses modulated by TREM2 are central to AD...
4.
Chen K, Martens Y, Meneses A, Ryu D, Lu W, Raulin A, et al.
Mol Neurodegener
. 2022 Sep;
17(1):57.
PMID: 36056345
Background: The aggregation and spread of α-synuclein (α-Syn) protein and related neuronal toxicity are the key pathological features of Parkinson's disease (PD) and Lewy body dementia (LBD). Studies have shown...
5.
Liu C, Zhao J, Fu Y, Inoue Y, Ren Y, Chen Y, et al.
Nat Neurosci
. 2022 Aug;
25(8):1020-1033.
PMID: 35915180
The ε4 allele of the apolipoprotein E (APOE) gene, a genetic risk factor for Alzheimer's disease, is abundantly expressed in both the brain and periphery. Here, we present evidence that...
6.
Liu C, Murray M, Li X, Zhao N, Wang N, Heckman M, et al.
Sci Transl Med
. 2021 Sep;
13(613):eabc9375.
PMID: 34586832
Apolipoprotein E () genetic variants have been shown to modify Alzheimer’s disease (AD) risk. We previously identified an variant (3-V236E), named -Jacksonville (-Jac), associated with healthy brain aging and reduced...
7.
Liu C, Yamazaki Y, Heckman M, Martens Y, Jia L, Yamazaki A, et al.
Alzheimers Dement
. 2020 Aug;
16(10):1372-1383.
PMID: 32827351
Introduction: Cerebrovascular pathologies including cerebral amyloid angiopathy (CAA) and blood-brain barrier (BBB) dysregulation are prominent features in the majority of Alzheimer's disease (AD) cases. Methods: We performed neuropathologic and biochemical...
8.
Zhao N, Attrebi O, Ren Y, Qiao W, Sonustun B, Martens Y, et al.
Sci Transl Med
. 2020 Feb;
12(529).
PMID: 32024798
The apolipoprotein E () ε4 allele is the strongest genetic risk factor for late-onset Alzheimer's disease mainly by driving amyloid-β pathology. Recently, has also been found to be a genetic...
9.
Zhao N, Liu C, Van Ingelgom A, Linares C, Kurti A, Knight J, et al.
Nat Commun
. 2018 Oct;
9(1):4388.
PMID: 30348994
Apolipoprotein E (APOE) ε4 allele is the strongest genetic risk factor for late-onset Alzheimer's disease mainly by modulating amyloid-β pathology. APOE ε4 is also shown to exacerbate neurodegeneration and neuroinflammation...
10.
Liu C, Zhao N, Fu Y, Wang N, Linares C, Tsai C, et al.
Neuron
. 2017 Dec;
96(5):1024-1032.e3.
PMID: 29216449
Accumulation and aggregation of amyloid-β (Aβ) in the brain is an initiating step in the pathogenesis of Alzheimer's disease (AD). The ε4 allele of apolipoprotein E (apoE) gene is the...