Curtis G Callan Jr
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Explore the profile of Curtis G Callan Jr including associated specialties, affiliations and a list of published articles.
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13
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1370
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Recent Articles
1.
Mayer A, Callan Jr C
Proc Natl Acad Sci U S A
. 2023 Jan;
120(4):e2213264120.
PMID: 36649423
Adaptive immunity is driven by specific binding of hypervariable receptors to diverse molecular targets. The sequence diversity of receptors and targets are both individually known but because multiple receptors can...
2.
Elhanati Y, Sethna Z, Callan Jr C, Mora T, Walczak A
Immunol Rev
. 2018 Jun;
284(1):167-179.
PMID: 29944757
Despite the extreme diversity of T-cell repertoires, many identical T-cell receptor (TCR) sequences are found in a large number of individual mice and humans. These widely shared sequences, often referred...
3.
Sethna Z, Elhanati Y, Dudgeon C, Callan Jr C, Levine A, Mora T, et al.
Proc Natl Acad Sci U S A
. 2017 Feb;
114(9):2253-2258.
PMID: 28196891
The ability of the adaptive immune system to respond to arbitrary pathogens stems from the broad diversity of immune cell surface receptors. This diversity originates in a stochastic DNA editing...
4.
Elhanati Y, Sethna Z, Marcou Q, Callan Jr C, Mora T, Walczak A
Philos Trans R Soc Lond B Biol Sci
. 2015 Jul;
370(1676).
PMID: 26194757
We quantify the VDJ recombination and somatic hypermutation processes in human B cells using probabilistic inference methods on high-throughput DNA sequence repertoires of human B-cell receptor heavy chains. Our analysis...
5.
Elhanati Y, Murugan A, Callan Jr C, Mora T, Walczak A
Proc Natl Acad Sci U S A
. 2014 Jun;
111(27):9875-80.
PMID: 24941953
The efficient recognition of pathogens by the adaptive immune system relies on the diversity of receptors displayed at the surface of immune cells. T-cell receptor diversity results from an initial...
6.
Murugan A, Mora T, Walczak A, Callan Jr C
Proc Natl Acad Sci U S A
. 2012 Sep;
109(40):16161-6.
PMID: 22988065
Stochastic rearrangement of germline V-, D-, and J-genes to create variable coding sequence for certain cell surface receptors is at the origin of immune system diversity. This process, known as...
7.
Melnikov A, Murugan A, Zhang X, Tesileanu T, Wang L, Rogov P, et al.
Nat Biotechnol
. 2012 Feb;
30(3):271-7.
PMID: 22371084
Learning to read and write the transcriptional regulatory code is of central importance to progress in genetic analysis and engineering. Here we describe a massively parallel reporter assay (MPRA) that...
8.
Kinney J, Murugan A, Callan Jr C, Cox E
Proc Natl Acad Sci U S A
. 2010 May;
107(20):9158-63.
PMID: 20439748
Cells use protein-DNA and protein-protein interactions to regulate transcription. A biophysical understanding of this process has, however, been limited by the lack of methods for quantitatively characterizing the interactions that...
9.
Mora T, Walczak A, Bialek W, Callan Jr C
Proc Natl Acad Sci U S A
. 2010 Mar;
107(12):5405-10.
PMID: 20212159
Recognition of pathogens relies on families of proteins showing great diversity. Here we construct maximum entropy models of the sequence repertoire, building on recent experiments that provide a nearly exhaustive...
10.
Tkacik G, Callan Jr C, Bialek W
Phys Rev E Stat Nonlin Soft Matter Phys
. 2008 Sep;
78(1 Pt 1):011910.
PMID: 18763985
Changes in a cell's external or internal conditions are usually reflected in the concentrations of the relevant transcription factors. These proteins in turn modulate the expression levels of the genes...