Csaba Ortutay
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Explore the profile of Csaba Ortutay including associated specialties, affiliations and a list of published articles.
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32
Citations
404
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Recent Articles
1.
Kakodkar P, More S, Andras K, Papakonstantinou N, Kelly S, Makrooni M, et al.
Cancers (Basel)
. 2020 Jul;
12(7).
PMID: 32664705
Treatment of chronic lymphocytic leukemia has advanced substantially as our understanding of the kinase signal transduction pathways driven by the B cell receptor (BcR) has developed. Particularly, understanding the role...
2.
Kutnyanszky V, Hargitai B, Hotzi B, Kosztelnik M, Ortutay C, Kovacs T, et al.
Mol Genet Genomics
. 2019 Nov;
295(2):357-371.
PMID: 31776761
Females and males differ substantially in various neuronal functions in divergent, sexually dimorphic animal species, including humans. Despite its developmental, physiological and medical significance, understanding the molecular mechanisms by which...
3.
Reilly E, Dhami S, Baev D, Ortutay C, Halpin-McCormick A, Morrell R, et al.
Sci Rep
. 2018 Oct;
8(1):15752.
PMID: 30361682
Acute myeloid leukaemia (AML) is an aggressive cancer with 50-75% of patients relapsing even after successful chemotherapy. The role of the bone marrow microenvironment (BMM) in protecting AML cells from...
4.
Hotzi B, Kosztelnik M, Hargitai B, Takacs-Vellai K, Barna J, Borden K, et al.
Aging Cell
. 2018 Mar;
17(3):e12724.
PMID: 29493066
A fascinating aspect of sexual dimorphism in various animal species is that the two sexes differ substantially in lifespan. In humans, for example, women's life expectancy exceeds that of men...
5.
Patrikainen M, Tolvanen M, Aspatwar A, Barker H, Ortutay C, Janis J, et al.
PeerJ
. 2017 Dec;
5:e4128.
PMID: 29230365
Background: Carbonic anhydrases (CAs) are ubiquitous, essential enzymes which catalyze the conversion of carbon dioxide and water to bicarbonate and H ions. Vertebrate genomes generally contain gene loci for 15-21...
6.
Aspatwar A, Tolvanen M, Ojanen M, Barker H, Saralahti A, Bauerlein C, et al.
PLoS One
. 2015 Jul;
10(7):e0134263.
PMID: 26218428
Carbonic anhydrase related proteins (CARPs) X and XI are highly conserved across species and are predominantly expressed in neural tissues. The biological role of these proteins is still an enigma....
7.
Ortutay Z, Oksanen A, Aittomaki S, Ortutay C, Pesu M
J Leukoc Biol
. 2015 May;
98(1):73-83.
PMID: 25926688
Antigen emergence rapidly stimulates T cells, which leads to changes in cytokine production, cell proliferation, and differentiation. Some of the key molecules involved in these events, such as TGF-β1 and...
8.
Valiaho J, Faisal I, Ortutay C, Smith C, Vihinen M
Hum Mutat
. 2015 Mar;
36(6):638-47.
PMID: 25777788
Knowledge about features distinguishing deleterious and neutral variations is crucial for interpretation of novel variants. Bruton tyrosine kinase (BTK) contains the highest number of unique disease-causing variations among the human...
9.
OReilly P, Ortutay C, Gernon G, OConnell E, Seoighe C, Boyce S, et al.
BMC Genomics
. 2014 Dec;
15:1144.
PMID: 25527049
Background: Identification of differentially expressed genes from transcriptomic studies is one of the most common mechanisms to identify tumor biomarkers. This approach however is not well suited to identify interaction...
10.
Angyan A, Ortutay C, Gaspari Z
J Mol Evol
. 2014 May;
78(5):263-74.
PMID: 24826911
Proteins are elaborate biopolymers balancing between contradicting intrinsic propensities to fold, aggregate, or remain disordered. Assessing their primary structural preferences observable without evolutionary optimization has been reinforced by the recent...