Crystal F Kline
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Explore the profile of Crystal F Kline including associated specialties, affiliations and a list of published articles.
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26
Citations
642
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Recent Articles
1.
El Refaey M, Coles S, Musa H, Stevens T, Wallace M, Murphy N, et al.
Cells
. 2022 Feb;
11(4).
PMID: 35203314
Zonula occludens-1 (ZO-1) is an intracellular scaffolding protein that orchestrates the anchoring of membrane proteins to the cytoskeleton in epithelial and specialized tissue including the heart. There is clear evidence...
2.
Roberts J, Murphy N, Hamilton R, Lubbers E, James C, Kline C, et al.
J Clin Invest
. 2019 Jul;
129(8):3171-3184.
PMID: 31264976
Arrhythmogenic cardiomyopathy (ACM) is an inherited arrhythmia syndrome characterized by severe structural and electrical cardiac phenotypes, including myocardial fibrofatty replacement and sudden cardiac death. Clinical management of ACM is largely...
3.
Williams J, Cavus O, Loccoh E, Adelman S, Daugherty J, Smith S, et al.
Life Sci
. 2018 Jan;
196:118-126.
PMID: 29366750
Aims: Right ventricular failure (RVF) varies significantly from the more common left ventricular failure (LVF). This study was undertaken to determine potential molecular pathways that are important in human right...
4.
Swayne L, Murphy N, Asuri S, Chen L, Xu X, McIntosh S, et al.
Circ Cardiovasc Genet
. 2017 Feb;
10(1).
PMID: 28196901
Background: Long QT syndrome confers susceptibility to ventricular arrhythmia, predisposing to syncope, seizures, and sudden death. While rare globally, long QT syndrome is ≈15× more common in First Nations of...
5.
Musa H, Murphy N, Curran J, Higgins J, Webb T, Makara M, et al.
Heart Rhythm
. 2016 Jun;
13(9):1932-40.
PMID: 27298202
Background: Human ANK2 (ankyrin-B) loss-of-function variants are directly linked with arrhythmia phenotypes. However, in atypical non-ion channel arrhythmia genes such as ANK2 that lack the same degree of robust structure/function...
6.
Smith S, Hughes L, Kline C, Kempton A, Dorn L, Curran J, et al.
Am J Physiol Heart Circ Physiol
. 2016 Apr;
310(11):H1583-91.
PMID: 27106045
β2-Spectrin is critical for integrating membrane and cytoskeletal domains in excitable and nonexcitable cells. The role of β2-spectrin for vertebrate function is illustrated by dysfunction of β2-spectrin-based pathways in disease....
7.
Musa H, Kline C, Sturm A, Murphy N, Adelman S, Wang C, et al.
Proc Natl Acad Sci U S A
. 2015 Sep;
112(40):12528-33.
PMID: 26392562
Nav channels are essential for metazoan membrane depolarization, and Nav channel dysfunction is directly linked with epilepsy, ataxia, pain, arrhythmia, myotonia, and irritable bowel syndrome. Human Nav channelopathies are primarily...
8.
Little S, Curran J, Makara M, Kline C, Ho H, Xu Z, et al.
Sci Signal
. 2015 Jul;
8(386):ra72.
PMID: 26198358
Protein phosphatase 2A (PP2A) is a serine/threonine-selective holoenzyme composed of a catalytic, scaffolding, and regulatory subunit. In the heart, PP2A activity is requisite for cardiac excitation-contraction coupling and central in...
9.
Neshatian L, Strege P, Rhee P, Kraichely R, Mazzone A, Bernard C, et al.
Am J Physiol Gastrointest Liver Physiol
. 2015 Jul;
309(6):G506-12.
PMID: 26185330
Human jejunum smooth muscle cells (SMCs) and interstitial cells of Cajal (ICCs) express the SCN5A-encoded voltage-gated, mechanosensitive sodium channel NaV1.5. NaV1.5 contributes to small bowel excitability, and NaV1.5 inhibitor ranolazine...
10.
Sturm A, Kline C, Glynn P, Johnson B, Curran J, Kilic A, et al.
J Am Heart Assoc
. 2015 May;
4(5).
PMID: 26015324
Background: Identified genetic variants are insufficient to explain all cases of inherited arrhythmia. We tested whether the integration of whole exome sequencing with well-established clinical, translational, and basic science platforms...