Cristina Pastorino
Overview
Explore the profile of Cristina Pastorino including associated specialties, affiliations and a list of published articles.
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8
Citations
84
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Recent Articles
1.
Romeo E, Saccoliti F, Ocello R, Andonaia A, Allegretta C, Pastorino C, et al.
J Med Chem
. 2025 Feb;
68(4):4596-4618.
PMID: 39928576
Molecular-targeted therapies for the treatment of cystic fibrosis (CF) rely on small-molecule modulators that rescue the activity of the defective CF transmembrane conductance regulator (CFTR) anion channel. is a small...
2.
Tomati V, Capurro V, Pesce E, Pastorino C, Sondo E, Lena M, et al.
Front Pharmacol
. 2024 Dec;
15:1494327.
PMID: 39624835
Introduction: Cystic Fibrosis (CF) is a genetic disease due to loss-of-function mutations of the CFTR channel. F508del is the most frequent mutation (70% of alleles in Italy), while other mutations...
3.
Terlizzi V, Pesce E, Capurro V, Tomati V, Lena M, Pastorino C, et al.
Int J Mol Sci
. 2023 Apr;
24(7).
PMID: 37047546
S737F is a Cystic Fibrosis (CF) transmembrane conductance regulator (CFTR) missense variant. The aim of our study was to describe the clinical features of a cohort of individuals carrying this...
4.
Baldassarri M, Zguro K, Tomati V, Pastorino C, Fava F, Croci S, et al.
Cells
. 2022 Dec;
11(24).
PMID: 36552859
Carriers of single pathogenic variants of the (cystic fibrosis transmembrane conductance regulator) gene have a higher risk of severe COVID-19 and 14-day death. The machine learning post-Mendelian model pinpointed as...
5.
Tomati V, Costa S, Capurro V, Pesce E, Pastorino C, Lena M, et al.
J Cyst Fibros
. 2022 Dec;
22(3):525-537.
PMID: 36543707
Background: Cystic fibrosis is caused by mutations impairing expression, trafficking, stability and/or activity of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel. The G1244E mutation causes a severe gating...
6.
Principi E, Sondo E, Bianchi G, Ravera S, Morini M, Tomati V, et al.
Cancers (Basel)
. 2022 Apr;
14(7).
PMID: 35406574
RNF5, an endoplasmic reticulum (ER) E3 ubiquitin ligase, participates to the ER-associated protein degradation guaranteeing the protein homeostasis. Depending on tumor model tested, RNF5 exerts pro- or anti-tumor activity. The...
7.
Parodi A, Righetti G, Pesce E, Salis A, Tomati V, Pastorino C, et al.
Pharmaceuticals (Basel)
. 2022 Mar;
15(3).
PMID: 35337072
Cystic fibrosis (CF) is a genetic disease affecting the lungs and pancreas and causing progressive damage. CF is caused by mutations abolishing the function of CFTR, a protein whose role...
8.
Sondo E, Cresta F, Pastorino C, Tomati V, Capurro V, Pesce E, et al.
Int J Mol Sci
. 2022 Mar;
23(6).
PMID: 35328596
Loss-of-function mutations of the gene cause cystic fibrosis (CF) through a variety of molecular mechanisms involving altered expression, trafficking, and/or activity of the CFTR chloride channel. The most frequent mutation...
9.
Capurro V, Tomati V, Sondo E, Renda M, Borrelli A, Pastorino C, et al.
Int J Mol Sci
. 2021 Jun;
22(10).
PMID: 34067708
Deletion of phenylalanine at position 508 (F508del) in the CFTR chloride channel is the most frequent mutation in cystic fibrosis (CF) patients. F508del impairs the stability and folding of the...