Cristina Mayor-Ruiz
Overview
Explore the profile of Cristina Mayor-Ruiz including associated specialties, affiliations and a list of published articles.
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20
Citations
478
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Recent Articles
1.
Alkhalaf L, Arrowsmith C, Balskus E, Bergamini G, Bhandari R, Chang C, et al.
Nat Chem Biol
. 2024 Dec;
21(1):6-15.
PMID: 39719500
No abstract available.
2.
Cigler M, Imrichova H, Frommelt F, Caramelle L, Depta L, Rukavina A, et al.
Nat Chem Biol
. 2024 Jun;
21(2):193-202.
PMID: 38907113
Metabolic alterations in cancer precipitate in associated dependencies that can be therapeutically exploited. To meet this goal, natural product-inspired small molecules can provide a resource of invaluable chemotypes. Here, we...
3.
Cacace A, Daniels D, Ferguson F, Mayor-Ruiz C, Woo C
Cell Chem Biol
. 2024 Jun;
31(6):1036-1038.
PMID: 38906107
In this Voices piece, the Cell Chemical Biology editors ask researchers from a range of backgrounds: what are some exciting discoveries in the induced proximity field and the next frontier...
4.
Whelan R, Mayor-Ruiz C
Nat Struct Mol Biol
. 2024 Feb;
31(2):205-207.
PMID: 38366231
No abstract available.
5.
Barbosa B, Sfyaki A, Rafael S, Jose-Duran F, Pous J, Sanchez-Zarzalejo C, et al.
Angew Chem Int Ed Engl
. 2023 Dec;
63(12):e202316730.
PMID: 38153885
Degraders hold the promise to efficiently inactivate previously intractable disease-relevant targets. Unlike traditional inhibitors, degraders act substoichiometrically and rely on the hijacked proteolysis machinery, which can also act as an...
6.
7.
Kozicka Z, Suchyta D, Focht V, Kempf G, Petzold G, Jentzsch M, et al.
Nat Chem Biol
. 2023 Sep;
20(1):93-102.
PMID: 37679459
Molecular glue degraders are an effective therapeutic modality, but their design principles are not well understood. Recently, several unexpectedly diverse compounds were reported to deplete cyclin K by linking CDK12-cyclin...
8.
Gonzalez L, Diaz L, Pous J, Baginski B, Duran-Corbera A, Scarpa M, et al.
Nat Commun
. 2023 Jun;
14(1):3318.
PMID: 37308482
p38α is a versatile protein kinase that can control numerous processes and plays important roles in the cellular responses to stress. Dysregulation of p38α signaling has been linked to several...
9.
Ward J, Perez-Lopez C, Mayor-Ruiz C
Chembiochem
. 2023 Apr;
24(10):e202300163.
PMID: 37018140
Degraders have illustrated that compound-induced proximity to E3 ubiquitin ligases can prompt the ubiquitination and degradation of disease-relevant proteins. Hence, this pharmacology is becoming a promising alternative and complement to...
10.
Domostegui A, Nieto-Barrado L, Perez-Lopez C, Mayor-Ruiz C
Chem Soc Rev
. 2022 Jun;
51(13):5498-5517.
PMID: 35723413
Protein-protein interactions (PPIs) govern all biological processes. Some small molecules modulate PPIs through induced protein proximity. In particular, molecular glue degraders are monovalent compounds that orchestrate interactions between a target...