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Cristina Florindo

Explore the profile of Cristina Florindo including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 19
Citations 162
Followers 0
Related Specialties
General Medicine
Biochemistry
Pharmacology
Top 10 Co-Authors
Isabel Tavares de Almeida
Rita Castro
Isabel Rivera
Ana Gaspar
Hana Pavlu-Pereira
A Catharine Ross
Thomas Neuberger
Maria Joao Silva
Madalena Barroso
Neil K Huang
Published In
Nutrients
Endocr Metab Immune Disord Drug Targets
Biomedicines
PLoS One
J Biol Chem
Affiliations
Soon will be listed here.
Recent Articles
1.
Sulphur Amino Acids: How Important is it to Set Reference Ranges for Each Population?
Araujo H, Florindo C, Gomes A, Caio J, Castro R, Rivera I
Endocr Metab Immune Disord Drug Targets . 2024 Jan; PMID: 38243971
Introduction: Metabolism of sulfur amino acids requires an optimal interplay between nutritional demand, enzymes, transporters, and adequate dietary intake of B vitamins. Insufficient intake and excess are detrimental, and concentrations...
2.
Evaluation of Mitochondrial Function on Pyruvate Dehydrogenase Complex Deficient Patient-derived Cell Lines
Pavlu-Pereira H, Florindo C, Carvalho F, Tavares de Almeida I, Vicente J, Morais V, et al.
Endocr Metab Immune Disord Drug Targets . 2023 Oct; PMID: 37861030
Introduction: Pyruvate Dehydrogenase Complex (PDC) is a pivotal gatekeeper between cytosolic glycolysis and mitochondrial oxidative phosphorylation, playing important role in aerobic energy metabolism. Most PDC deficiency, cases being caused by...
3.
Glutaric Acidemia Type 1: Diagnosis, Clinical features, and Outcome in a Portuguese Cohort
Lipari Pinto P, Camara B, Florindo C, Loureiro R, Jardim I, Sousa C, et al.
Endocr Metab Immune Disord Drug Targets . 2023 Sep; PMID: 37711119
Introduction: Glutaric acidemia type 1 (GA1) is a rare autosomal recessive disorder characterized by a deficiency of glutaryl-CoA dehydrogenase, resulting in the accumulation of glutaric acid (GA), 3-hydroxyglutaric acid, and...
4.
Acquired Vitamin B12 Deficiency in Newborns: Positive Impact on Newborn Health through Early Detection
Lipari Pinto P, Florindo C, Janeiro P, Santos R, Mexia S, Rocha H, et al.
Nutrients . 2022 Oct; 14(20). PMID: 36297083
The early diagnosis of and intervention in vitamin B12 deficiency in exclusively breastfed infants by mothers with low vitamin B12 is crucial in preventing possible irreversible neurologic damage, megaloblastic anemia,...
5.
The Effect of Nutritional Ketosis on Aquaporin Expression in Apolipoprotein E-Deficient Mice: Potential Implications for Energy Homeostasis
da Silva I, Gullette S, Florindo C, Huang N, Neuberger T, Ross A, et al.
Biomedicines . 2022 May; 10(5). PMID: 35625895
Ketogenic diets (KDs) are very low-carbohydrate, very high-fat diets which promote nutritional ketosis and impact energetic metabolism. Aquaporins (AQPs) are transmembrane channels that facilitate water and glycerol transport across cell...
6.
A Hypomethylating Ketogenic Diet in Apolipoprotein E-Deficient Mice: A Pilot Study on Vascular Effects and Specific Epigenetic Changes
Castro R, Whalen C, Gullette S, Mattie F, Florindo C, Heil S, et al.
Nutrients . 2021 Oct; 13(10). PMID: 34684577
Hyperhomocysteneinemia (HHcy) is common in the general population and is a risk factor for atherosclerosis by mechanisms that are still elusive. A hypomethylated status of epigenetically relevant targets may contribute...
7.
Structural and functional impact of clinically relevant E1α variants causing pyruvate dehydrogenase complex deficiency
Pavlu-Pereira H, Lousa D, Tome C, Florindo C, Silva M, Tavares de Almeida I, et al.
Biochimie . 2021 Feb; 183:78-88. PMID: 33588022
Pyruvate dehydrogenase complex (PDC) catalyzes the oxidative decarboxylation of pyruvate to acetyl-coenzyme A, hinging glycolysis and the tricarboxylic acid cycle. PDC deficiency, an inborn error of metabolism, has a broad...
8.
An Atherogenic Diet Disturbs Expression in Liver and Adipocyte Tissues of Apolipoprotein E-Deficient Mice: New Insights into an Old Model of Experimental Atherosclerosis
da Silva I, Whalen C, Mattie F, Florindo C, Huang N, Heil S, et al.
Biomedicines . 2021 Feb; 9(2). PMID: 33557105
The dysfunction of vascular endothelial cells is profoundly implicated in the pathogenesis of atherosclerosis and cardiovascular disease, the global leading cause of death. Aquaporins (AQPs) are membrane channels that facilitate...
9.
Pyruvate dehydrogenase complex deficiency: updating the clinical, metabolic and mutational landscapes in a cohort of Portuguese patients
Pavlu-Pereira H, Silva M, Florindo C, Sequeira S, Ferreira A, Duarte S, et al.
Orphanet J Rare Dis . 2020 Oct; 15(1):298. PMID: 33092611
Background: The pyruvate dehydrogenase complex (PDC) catalyzes the irreversible decarboxylation of pyruvate into acetyl-CoA. PDC deficiency can be caused by alterations in any of the genes encoding its several subunits....
10.
No Effect of Diet-Induced Mild Hyperhomocysteinemia on Vascular Methylating Capacity, Atherosclerosis Progression, and Specific Histone Methylation
Whalen C, Mattie F, Florindo C, van Zelst B, Huang N, Tavares de Almeida I, et al.
Nutrients . 2020 Jul; 12(8). PMID: 32717800
Hyperhomocysteinemia (HHcy) is a risk factor for atherosclerosis through mechanisms which are still incompletely defined. One possible mechanism involves the hypomethylation of the nuclear histone proteins to favor the progression...