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Craig Leighton

Explore the profile of Craig Leighton including associated specialties, affiliations and a list of published articles. Areas
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Articles 5
Citations 25
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Recent Articles
1.
Chappard A, Leighton C, Saleeb R, Jeacock K, Ball S, Morris K, et al.
Angew Chem Weinheim Bergstr Ger . 2024 Mar; 135(15):e202216771. PMID: 38516037
Protein misfolding and aggregation into oligomeric and fibrillar structures is a common feature of many neurogenerative disorders. Single-molecule techniques have enabled characterization of these lowly abundant, highly heterogeneous protein aggregates,...
2.
Saleeb R, Leighton C, Lee J, OShaughnessy J, Jeacock K, Chappard A, et al.
Sci Adv . 2023 Nov; 9(46):eadi7359. PMID: 37967183
Protein misfolding and aggregation is a characteristic of many neurodegenerative disorders, including Alzheimer's and Parkinson's disease. The oligomers generated during aggregation are likely involved in disease pathogenesis and present promising...
3.
DSa K, Evans J, Virdi G, Vecchi G, Adam A, Bertolli O, et al.
Nat Mach Intell . 2023 Aug; 5(8):933-946. PMID: 37615030
Parkinson's disease is a common, incurable neurodegenerative disorder that is clinically heterogeneous: it is likely that different cellular mechanisms drive the pathology in different individuals. So far it has not...
4.
Chappard A, Leighton C, Saleeb R, Jeacock K, Ball S, Morris K, et al.
Angew Chem Int Ed Engl . 2023 Feb; 62(15):e202216771. PMID: 36762870
Protein misfolding and aggregation into oligomeric and fibrillar structures is a common feature of many neurogenerative disorders. Single-molecule techniques have enabled characterization of these lowly abundant, highly heterogeneous protein aggregates,...
5.
Virdi G, Choi M, Evans J, Yao Z, Athauda D, Strohbuecker S, et al.
NPJ Parkinsons Dis . 2022 Nov; 8(1):162. PMID: 36424392
Mutations in the SNCA gene cause autosomal dominant Parkinson's disease (PD), with loss of dopaminergic neurons in the substantia nigra, and aggregation of α-synuclein. The sequence of molecular events that...