Craig Lapsley
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Explore the profile of Craig Lapsley including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
157
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Recent Articles
1.
Damasceno J, Briggs E, Krasilnikova M, Marques C, Lapsley C, McCulloch R
Nat Commun
. 2025 Feb;
16(1):1470.
PMID: 39922816
Genomes in eukaryotes normally undergo DNA replication in a choreographed temporal order, resulting in early and late replicating chromosome compartments. Leishmania, a human protozoan parasite, displays an unconventional DNA replication...
2.
Krasilnikova M, Marques C, Briggs E, Lapsley C, Hamilton G, Beraldi D, et al.
Nat Commun
. 2025 Jan;
16(1):751.
PMID: 39820334
The Trypanosoma brucei genome is structurally complex. Eleven megabase-sized chromosomes each comprise a transcribed core flanked by silent subtelomeres, housing thousands of Variant Surface Glycoprotein (VSG) genes. Additionally, hundreds of...
3.
Girasol M, Krasilnikova M, Marques C, Damasceno J, Lapsley C, Lemgruber L, et al.
Proc Natl Acad Sci U S A
. 2023 Nov;
120(48):e2309306120.
PMID: 37988471
RNA-DNA hybrids are epigenetic features of all genomes that intersect with many processes, including transcription, telomere homeostasis, and centromere function. Increasing evidence suggests that RNA-DNA hybrids can provide two conflicting...
4.
Dener Damasceno J, Marques C, Beraldi D, Crouch K, Lapsley C, Obonaga R, et al.
Elife
. 2020 Sep;
9.
PMID: 32897188
DNA replication is needed to duplicate a cell's genome in S phase and segregate it during cell division. Previous work in detected DNA replication initiation at just a single region...
5.
Damasceno J, Reis-Cunha J, Crouch K, Beraldi D, Lapsley C, Tosi L, et al.
PLoS Genet
. 2020 Jul;
16(7):e1008828.
PMID: 32609721
Homologous recombination (HR) has an intimate relationship with genome replication, both during repair of DNA lesions that might prevent DNA synthesis and in tackling stalls to the replication fork. Recent...
6.
Black J, Crouch K, Lemgruber L, Lapsley C, Dickens N, Tosi L, et al.
Cell Rep
. 2020 Jan;
30(3):836-851.e5.
PMID: 31968257
Trypanosoma brucei evades mammalian immunity by using recombination to switch its surface-expressed variant surface glycoprotein (VSG), while ensuring that only one of many subtelomeric multigene VSG expression sites are transcribed...
7.
Briggs E, Crouch K, Lemgruber L, Hamilton G, Lapsley C, McCulloch R
Nucleic Acids Res
. 2019 Jul;
47(17):9180-9197.
PMID: 31350892
Ribonucleotides represent a threat to DNA genome stability and transmission. Two types of Ribonuclease H (RNase H) excise ribonucleotides when they form part of the DNA strand, or hydrolyse RNA...
8.
Briggs E, Crouch K, Lemgruber L, Lapsley C, McCulloch R
PLoS Genet
. 2018 Dec;
14(12):e1007729.
PMID: 30543624
Switching of the Variant Surface Glycoprotein (VSG) in Trypanosoma brucei provides a crucial host immune evasion strategy that is catalysed both by transcription and recombination reactions, each operating within specialised...
9.
Briggs E, Hamilton G, Crouch K, Lapsley C, McCulloch R
Nucleic Acids Res
. 2018 Oct;
46(22):11789-11805.
PMID: 30304482
R-loops are stable RNA-DNA hybrids that have been implicated in transcription initiation and termination, as well as in telomere maintenance, chromatin formation, and genome replication and instability. RNA Polymerase (Pol)...
10.
Devlin R, Marques C, Paape D, Prorocic M, Zurita-Leal A, Campbell S, et al.
Elife
. 2016 May;
5.
PMID: 27228154
Survival of Trypanosoma brucei depends upon switches in its protective Variant Surface Glycoprotein (VSG) coat by antigenic variation. VSG switching occurs by frequent homologous recombination, which is thought to require...