Craig L Bohrson
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Explore the profile of Craig L Bohrson including associated specialties, affiliations and a list of published articles.
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12
Citations
994
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Recent Articles
1.
Ganz J, Luquette L, Bizzotto S, Miller M, Zhou Z, Bohrson C, et al.
Cell
. 2024 Mar;
187(8):1955-1970.e23.
PMID: 38503282
Characterizing somatic mutations in the brain is important for disentangling the complex mechanisms of aging, yet little is known about mutational patterns in different brain cell types. Here, we performed...
2.
Rodin R, Dou Y, Kwon M, Sherman M, DGama A, Doan R, et al.
Nat Neurosci
. 2023 Aug;
26(10):1833.
PMID: 37644260
No abstract available.
3.
Ganz J, Luquette L, Bizzotto S, Bohrson C, Jin H, Miller M, et al.
bioRxiv
. 2023 Jan;
PMID: 36711756
Characterizing the mechanisms of somatic mutations in the brain is important for understanding aging and disease, but little is known about the mutational patterns of different cell types. We performed...
4.
Luquette L, Miller M, Zhou Z, Bohrson C, Zhao Y, Jin H, et al.
Nat Genet
. 2022 Sep;
54(10):1564-1571.
PMID: 36163278
Accurate somatic mutation detection from single-cell DNA sequencing is challenging due to amplification-related artifacts. To reduce this artifact burden, an improved amplification technique, primary template-directed amplification (PTA), was recently introduced....
5.
Rodin R, Dou Y, Kwon M, Sherman M, DGama A, Doan R, et al.
Nat Neurosci
. 2021 Mar;
24(4):611.
PMID: 33753946
No abstract available.
6.
Bizzotto S, Dou Y, Ganz J, Doan R, Kwon M, Bohrson C, et al.
Science
. 2021 Mar;
371(6535):1249-1253.
PMID: 33737485
Although cell lineage information is fundamental to understanding organismal development, very little direct information is available for humans. We performed high-depth (250×) whole-genome sequencing of multiple tissues from three individuals...
7.
Rodin R, Dou Y, Kwon M, Sherman M, DGama A, Doan R, et al.
Nat Neurosci
. 2021 Jan;
24(2):176-185.
PMID: 33432195
We characterize the landscape of somatic mutations-mutations occurring after fertilization-in the human brain using ultra-deep (~250×) whole-genome sequencing of prefrontal cortex from 59 donors with autism spectrum disorder (ASD) and...
8.
Touat M, Li Y, Boynton A, Spurr L, Iorgulescu J, Bohrson C, et al.
Nature
. 2020 Apr;
580(7804):517-523.
PMID: 32322066
A high tumour mutational burden (hypermutation) is observed in some gliomas; however, the mechanisms by which hypermutation develops and whether it predicts the response to immunotherapy are poorly understood. Here...
9.
Luquette L, Bohrson C, Sherman M, Park P
Nat Commun
. 2019 Aug;
10(1):3908.
PMID: 31467286
Recent advances in single cell technology have enabled dissection of cellular heterogeneity in great detail. However, analysis of single cell DNA sequencing data remains challenging due to bias and artifacts...
10.
Bohrson C, Barton A, Lodato M, Rodin R, Luquette L, Viswanadham V, et al.
Nat Genet
. 2019 Mar;
51(4):749-754.
PMID: 30886424
Whole-genome sequencing of DNA from single cells has the potential to reshape our understanding of mutational heterogeneity in normal and diseased tissues. However, a major difficulty is distinguishing amplification artifacts...