Craig Hughes
Overview
Explore the profile of Craig Hughes including associated specialties, affiliations and a list of published articles.
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Articles
4
Citations
180
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Recent Articles
1.
Li B, Ponjavic A, Chen W, Hopkins L, Hughes C, Ye Y, et al.
Anal Chem
. 2021 Feb;
93(8):4092-4099.
PMID: 33595281
The detection of single molecules in biological systems has rapidly increased in resolution over the past decade. However, the delivery of single molecules remains to be a challenge. Currently, there...
2.
Hughes C, Choi M, Yi J, Kim S, Drews A, St George-Hyslop P, et al.
Commun Biol
. 2020 Feb;
3(1):79.
PMID: 32071389
The molecular events causing memory loss and neuronal cell death in Alzheimer's disease (AD) over time are still unknown. Here we found that picomolar concentrations of soluble oligomers of synthetic...
3.
De S, Whiten D, Ruggeri F, Hughes C, Rodrigues M, Sideris D, et al.
Acta Neuropathol Commun
. 2019 Jul;
7(1):120.
PMID: 31349874
Soluble aggregates of amyloid-β (Aβ) have been associated with neuronal and synaptic loss in Alzheimer's disease (AD). However, despite significant recent progress, the mechanisms by which these aggregated species contribute...
4.
Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms
De S, Wirthensohn D, Flagmeier P, Hughes C, Aprile F, Ruggeri F, et al.
Nat Commun
. 2019 Apr;
10(1):1541.
PMID: 30948723
Protein aggregation is a complex process resulting in the formation of heterogeneous mixtures of aggregate populations that are closely linked to neurodegenerative conditions, such as Alzheimer's disease. Here, we find...