Courtney J Mercadante
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Explore the profile of Courtney J Mercadante including associated specialties, affiliations and a list of published articles.
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8
Citations
131
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Recent Articles
1.
Prajapati M, Zhang J, Chong G, Chiu L, Mercadante C, Kowalski H, et al.
Cell Mol Gastroenterol Hepatol
. 2025 Mar;
:101489.
PMID: 40024532
Background And Aims: SLC11A2 (DMT1) and SLC40A1 (ferroportin) are essential for dietary iron absorption, but their role in manganese transport is debated. SLC30A10 deficiency causes severe manganese excess due to...
2.
Prajapati M, Zhang J, Chong G, Chiu L, Mercadante C, Kowalski H, et al.
bioRxiv
. 2024 Jul;
PMID: 39071439
SLC30A10 deficiency is a disease of severe manganese excess attributed to loss of SLC30A10-dependent manganese excretion via the gastrointestinal tract. Patients develop dystonia, cirrhosis, and polycythemia. They are treated with...
3.
Prajapati M, Zhang J, Chiu L, Chong G, Mercadante C, Kowalski H, et al.
JCI Insight
. 2024 Apr;
9(10).
PMID: 38652538
Manganese is an essential yet potentially toxic metal. Initially reported in 2012, mutations in SLC30A10 are the first known inherited cause of manganese excess. SLC30A10 is an apical membrane protein...
4.
Prajapati M, Zhang J, Mercadante C, Kowalski H, Delaney B, Anderson J, et al.
bioRxiv
. 2023 Mar;
PMID: 36865210
Manganese is an essential yet potentially toxic metal. Initially reported in 2012, mutations in SLC30A10 are the first known inherited cause of manganese excess. SLC30A10 is an apical membrane transport...
5.
Prajapati M, Pettiglio M, Conboy H, Mercadante C, Hojyo S, Fukada T, et al.
Biometals
. 2021 Mar;
34(3):573-588.
PMID: 33713241
Manganese (Mn), an essential metal, can be toxic at elevated levels. In 2012, the first inherited cause of Mn excess was reported in patients with mutations in SLC30A10, a Mn...
6.
Mercadante C, Prajapati M, Conboy H, Dash M, Herrera C, Pettiglio M, et al.
J Clin Invest
. 2019 Sep;
129(12):5442-5461.
PMID: 31527311
Manganese (Mn), an essential metal and nutrient, is toxic in excess. Toxicity classically results from inhalational exposures in individuals who work in industrial settings. The first known disease of inherited...
7.
Mercadante C, Prajapati M, Parmar J, Conboy H, Dash M, Pettiglio M, et al.
Haematologica
. 2018 Nov;
104(4):678-689.
PMID: 30409795
The current paradigm in the field of mammalian iron biology states that body iron levels are determined by dietary iron absorption, not by iron excretion. Iron absorption is a highly...
8.
Mercadante C, Herrera C, Pettiglio M, Foster M, Johnson L, Dorman D, et al.
Biometals
. 2016 Mar;
29(3):417-22.
PMID: 26988220
Manganese is an essential dietary nutrient and trace element with important roles in mammalian development, metabolism, and antioxidant defense. In healthy individuals, gastrointestinal absorption and hepatobiliary excretion are tightly regulated...
9.
McAllaster M, Ikeda K, Lozano-Nunez A, Anrather D, Unterwurzacher V, Gossenreiter T, et al.
Mol Biol Cell
. 2015 Jul;
26(17):3013-29.
PMID: 26133384
Trypanosoma brucei is the causative agent of African sleeping sickness, a devastating disease endemic to sub-Saharan Africa with few effective treatment options. The parasite is highly polarized, including a single...