Corwyn Hopke
Overview
Explore the profile of Corwyn Hopke including associated specialties, affiliations and a list of published articles.
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10
Citations
421
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Recent Articles
1.
Huan J, Kaler L, Mooney J, Subramanian S, Hopke C, Vandenbark A, et al.
J Immunol
. 2008 Jan;
180(2):1249-57.
PMID: 18178865
We previously demonstrated the therapeutic effects of MHC class II derived recombinant T cell receptor ligands (RTL), single-chain two domain complexes of the alpha1 and beta1 domains of MHC class...
2.
Polanczyk M, Hopke C, Vandenbark A, Offner H
Int Immunol
. 2007 Feb;
19(3):337-43.
PMID: 17267414
Estrogen [17-beta-estradiol (E2)] is a potent driver of the FoxP3+ regulatory T cell (Treg) compartment. Recently, Tregs were further characterized by intracellular expression of the negative co-stimulatory molecule, programmed death-1...
3.
Polanczyk M, Hopke C, Vandenbark A, Offner H
J Neurosci Res
. 2006 May;
84(2):370-8.
PMID: 16676326
Estrogen (E2)-induced immunomodulation involves dual effects on antigen-presenting cells (APC) and CD4(+)CD25(+) regulatory T cells (Treg) but not a direct effect on effector T cells. In this report, we further...
4.
Polanczyk M, Hopke C, Huan J, Vandenbark A, Offner H
J Neuroimmunol
. 2005 Oct;
170(1-2):85-92.
PMID: 16253347
Estrogen (E2) upregulates the FoxP3 gene that marks regulatory CD4+CD25+ T cells (Treg cells). However, E2 also inhibits the ability of antigen presenting cells (APC) to activate T cells. It...
5.
Matejuk A, Hopke C, Vandenbark A, Hurn P, Offner H
J Immunol
. 2005 Feb;
174(4):2387-95.
PMID: 15699175
Treatment with sex hormones is known to protect against experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis. However, little is known about how age affects the course of...
6.
Matejuk A, Bakke A, Hopke C, Dwyer J, Vandenbark A, Offner H
J Neurosci Res
. 2004 Jun;
77(1):119-26.
PMID: 15197745
Multiple sclerosis (MS) is a debilitating neurological disease characterized by a progressive loss of motor and sensory function, eventually leading to paralysis and death. The primary cause of neurological impairment...
7.
Matejuk A, Dwyer J, Hopke C, Vandenbark A, Offner H
Cytokine
. 2003 Dec;
25(2):45-51.
PMID: 14693159
Hormones can exert significant protective effects on autoimmune diseases by activating immunoregulatory mechanisms. One of the possible mechanisms of hormonal protection might be through the anti-inflammatory effects of the TGF-beta...
8.
Matejuk A, Hopke C, Dwyer J, Subramanian S, Jones R, Bourdette D, et al.
J Neurosci Res
. 2003 Aug;
73(5):667-78.
PMID: 12929134
Transgenic mice with T-cell receptor (TCR) specific for myelin basic protein (MBP)-Ac1-11 peptide and homozygous for the RAG-1 mutation (T/R- mice) spontaneously develop acute progressive experimental autoimmune encephalomyelitis (Sp-EAE) mediated...
9.
Matejuk A, Dwyer J, Hopke C, Vandenbark A, Offner H
Arch Immunol Ther Exp (Warsz)
. 2003 Aug;
51(3):185-93.
PMID: 12894873
It is now well documented that experimental autoimmune encephalomyelitis (EAE) can be effectively prevented by estrogen therapy. Previously, we identified a limited set of genes that were altered in spleens...
10.
Ito A, Matejuk A, Hopke C, Drought H, Dwyer J, Zamora A, et al.
J Immunol
. 2003 Apr;
170(9):4802-9.
PMID: 12707362
The aim of this study was to evaluate the roles of IL-18 and IL-12 in potentiating the encephalitogenic activity of T cell lines specific for myelin oligodendrocyte glycoprotein (MOG(35-55)). MOG-specific...