Cornelis P J Bekker
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Explore the profile of Cornelis P J Bekker including associated specialties, affiliations and a list of published articles.
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32
Citations
1076
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Recent Articles
1.
Hamkour S, van der Heijden E, Lopes A, Blokland S, Bekker C, van Helden-Meeuwsen C, et al.
RMD Open
. 2023 Aug;
9(3).
PMID: 37532471
Objectives: To assess to what extent leflunomide (LEF) and hydroxychloroquine (HCQ) therapy in patients with primary Sjögren's syndrome (RepurpSS-I) targets type I IFN-associated responses and to study the potential of...
2.
Servaas N, Hiddingh S, Chouri E, Wichers C, Affandi A, Ottria A, et al.
Arthritis Rheumatol
. 2022 Dec;
75(2):279-292.
PMID: 36482877
Objective: This study was undertaken to identify key disease pathways driving conventional dendritic cell (cDC) alterations in systemic sclerosis (SSc). Methods: Transcriptomic profiling was performed on peripheral blood CD1c+ cDCs...
3.
Vincken N, Welsing P, Silva-Cardoso S, Bekker C, Lopes A, Nordkamp M, et al.
Exp Dermatol
. 2022 Mar;
31(6):962-969.
PMID: 35297512
Interleukin (IL)-12 and IL-23 are pro-inflammatory cytokines produced by dendritic cells (DCs) and associated with Psoriasis (Pso) and Psoriatic Arthritis (PsA) pathogenesis. Tofacitinib, a Janus kinase inhibitor, effectively suppresses inflammatory...
4.
Affandi A, Carvalheiro T, Ottria A, de Haan J, Brans M, Brandt M, et al.
Cell Rep
. 2022 Jan;
38(1):110189.
PMID: 34986347
Fibrosis is a major cause of mortality worldwide, characterized by myofibroblast activation and excessive extracellular matrix deposition. Systemic sclerosis is a prototypic fibrotic disease in which CXCL4 is increased and...
5.
Ottria A, Zimmermann M, Paardekooper L, Carvalheiro T, Vazirpanah N, Silva-Cardoso S, et al.
Rheumatology (Oxford)
. 2021 Sep;
61(6):2682-2693.
PMID: 34559222
Objective: SSc is a complex disease characterized by vascular abnormalities and inflammation culminating in hypoxia and excessive fibrosis. Previously, we identified chemokine (C-X-C motif) ligand 4 (CXCL4) as a novel...
6.
Lopes A, Bekker C, Hillen M, Blokland S, Hinrichs A, Pandit A, et al.
Front Immunol
. 2021 Aug;
12:701656.
PMID: 34413853
Primary Sjögren's syndrome (pSS) is a systemic autoimmune disease characterized by infiltration of the exocrine glands and prominent B cell hyperactivity. Considering the key role of monocytes in promoting B...
7.
Angiolilli C, Leijten E, Bekker C, Eeftink E, Giovannone B, Nordkamp M, et al.
J Invest Dermatol
. 2021 Aug;
142(2):402-413.
PMID: 34333017
Dermal fibroblasts are strategically positioned underneath the basal epidermis layer to support keratinocyte proliferation and extracellular matrix production. In inflammatory conditions, these fibroblasts produce cytokines and chemokines that promote the...
8.
Chouri E, Wang M, Hillen M, Angiolilli C, Silva-Cardoso S, Wichers C, et al.
J Clin Med
. 2021 Feb;
10(3).
PMID: 33573268
Compelling evidence shows the involvement of plasmacytoid dendritic cells (pDCs) in systemic sclerosis (SSc) pathogenesis. This study investigated whether microRNAs (miRNAs) are involved in the dysregulation of pDCs in SSc...
9.
Silva-Cardoso S, Tao W, Angiolilli C, Lopes A, Bekker C, Devaprasad A, et al.
Front Immunol
. 2020 Oct;
11:2149.
PMID: 33042127
Fibrosis is a condition shared by numerous inflammatory diseases. Our incomplete understanding of the molecular mechanisms underlying fibrosis has severely hampered effective drug development. CXCL4 is associated with the onset...
10.
van der Kroef M, Carvalheiro T, Rossato M, de Wit F, Cossu M, Chouri E, et al.
J Autoimmun
. 2020 Apr;
111:102444.
PMID: 32284212
Objective: To analyze how monocyte and macrophage exposure to CXCL4 induces inflammatory and fibrotic processes observed in Systemic sclerosis (SSc) patients. Methods: In six independent experiments, monocytes of healthy controls...