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Corey E Bakalarski

Explore the profile of Corey E Bakalarski including associated specialties, affiliations and a list of published articles. Areas
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Recent Articles
11.
Dey A, Seshasayee D, Noubade R, French D, Liu J, Chaurushiya M, et al.
Science . 2012 Aug; 337(6101):1541-6. PMID: 22878500
De-ubiquitinating enzyme BAP1 is mutated in a hereditary cancer syndrome with increased risk of mesothelioma and uveal melanoma. Somatic BAP1 mutations occur in various malignancies. We show that mouse Bap1...
12.
Bustos D, Bakalarski C, Yang Y, Peng J, Kirkpatrick D
Mol Cell Proteomics . 2012 Jun; 11(12):1529-40. PMID: 22729469
Advances in high resolution tandem mass spectrometry and peptide enrichment technologies have transformed the field of protein biochemistry by enabling analysis of end points that have traditionally been inaccessible to...
13.
Pham V, Pitti R, Anania V, Bakalarski C, Bustos D, Jhunjhunwala S, et al.
J Proteome Res . 2012 Mar; 11(5):2947-54. PMID: 22432722
Proteolysis is a key regulatory event that controls intracellular and extracellular signaling through irreversible changes in a protein's structure that greatly alters its function. Here we describe a platform for...
14.
Phu L, Izrael-Tomasevic A, Matsumoto M, Bustos D, Dynek J, Fedorova A, et al.
Mol Cell Proteomics . 2010 Nov; 10(5):M110.003756. PMID: 21048196
Ubiquitinated substrates can be recruited to macromolecular complexes through interactions between their covalently bound ubiquitin (Ub) signals and Ub receptor proteins. To develop a functional understanding of the Ub system...
15.
Bakalarski C, Elias J, Villen J, Haas W, Gerber S, Everley P, et al.
J Proteome Res . 2008 Sep; 7(11):4756-65. PMID: 18798661
Recently, mass spectrometry has been employed in many studies to provide unbiased, reproducible, and quantitative protein abundance information on a proteome-wide scale. However, how instruments' limited dynamic ranges impact the...
16.
Dephoure N, Zhou C, Villen J, Beausoleil S, Bakalarski C, Elledge S, et al.
Proc Natl Acad Sci U S A . 2008 Aug; 105(31):10762-7. PMID: 18669648
The eukaryotic cell division cycle is characterized by a sequence of orderly and highly regulated events resulting in the duplication and separation of all cellular material into two newly formed...
17.
Rikova K, Guo A, Zeng Q, Possemato A, Yu J, Haack H, et al.
Cell . 2007 Dec; 131(6):1190-203. PMID: 18083107
Despite the success of tyrosine kinase-based cancer therapeutics, for most solid tumors the tyrosine kinases that drive disease remain unknown, limiting our ability to identify drug targets and predict response....
18.
Bakalarski C, Haas W, Dephoure N, Gygi S
Anal Bioanal Chem . 2007 Sep; 389(5):1409-19. PMID: 17874083
Proteomic analyses via tandem mass spectrometry have been greatly enhanced by the recent development of fast, highly accurate instrumentation. However, successful application of these developments to high-throughput experiments requires careful...
19.
Matsuoka S, Ballif B, Smogorzewska A, McDonald 3rd E, Hurov K, Luo J, et al.
Science . 2007 May; 316(5828):1160-6. PMID: 17525332
Cellular responses to DNA damage are mediated by a number of protein kinases, including ATM (ataxia telangiectasia mutated) and ATR (ATM and Rad3-related). The outlines of the signal transduction portion...
20.
Gartner C, Elias J, Bakalarski C, Gygi S
J Proteome Res . 2007 Feb; 6(4):1482-91. PMID: 17311443
The relative quantification of protein expression levels in different cell samples through the utilization of stable isotope dilution has become a standard method in the field of proteomics. We describe...