Constanze Depp
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Explore the profile of Constanze Depp including associated specialties, affiliations and a list of published articles.
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15
Citations
353
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Recent Articles
1.
Sasmita A, Ong E, Nazarenko T, Mao S, Komarek L, Thalmann M, et al.
Neuron
. 2025 Jan;
PMID: 39837326
In Alzheimer's disease (AD) research, the 5xFAD mouse model is commonly used as a heterozygote crossed with other genetic models to study AD pathology. We investigated whether the parental origin...
2.
Kaji S, Berghoff S, Spieth L, Schlaphoff L, Sasmita A, Vitale S, et al.
Immunity
. 2024 Dec;
58(1):263.
PMID: 39637851
No abstract available.
3.
Kaji S, Berghoff S, Spieth L, Schlaphoff L, Sasmita A, Vitale S, et al.
Immunity
. 2024 Oct;
57(11):2651-2668.e12.
PMID: 39419029
The seeded growth of pathogenic protein aggregates underlies the pathogenesis of Alzheimer's disease (AD), but how this pathological cascade is initiated is not fully understood. Sporadic AD is linked genetically...
4.
Sasmita A, Depp C, Nazarenko T, Sun T, Siems S, Ong E, et al.
Nat Neurosci
. 2024 Aug;
27(9):1668-1674.
PMID: 39103558
Amyloid-β (Aβ) is thought to be neuronally derived in Alzheimer's disease (AD). However, transcripts of amyloid precursor protein (APP) and amyloidogenic enzymes are equally abundant in oligodendrocytes (OLs). By cell-type-specific...
5.
Spate E, Zhou B, Sun T, Kusch K, Asadollahi E, Siems S, et al.
Glia
. 2024 Apr;
72(8):1374-1391.
PMID: 38587131
Oligodendrocytes and astrocytes are metabolically coupled to neuronal compartments. Pyruvate and lactate can shuttle between glial cells and axons via monocarboxylate transporters. However, lactate can only be synthesized or used...
6.
Depp C, Sun T, Sasmita A, Spieth L, Berghoff S, Nazarenko T, et al.
Nature
. 2023 May;
618(7964):349-357.
PMID: 37258678
The incidence of Alzheimer's disease (AD), the leading cause of dementia, increases rapidly with age, but why age constitutes the main risk factor is still poorly understood. Brain ageing affects...
7.
Arinrad S, Depp C, Siems S, Sasmita A, Eichel M, Ronnenberg A, et al.
Elife
. 2023 Mar;
12.
PMID: 36892455
A key feature of advanced brain aging includes structural defects of intracortical myelin that are associated with secondary neuroinflammation. A similar pathology is seen in specific myelin mutant mice that...
8.
Katsalifis A, Casaril A, Depp C, Bas-Orth C
J Vis Exp
. 2021 Nov;
(176).
PMID: 34747400
Mitochondrial redox homeostasis is important for neuronal viability and function. Although mitochondria contain several redox systems, the highly abundant thiol-disulfide redox buffer glutathione is considered a central player in antioxidant...
9.
Berghoff S, Spieth L, Sun T, Hosang L, Depp C, Sasmita A, et al.
Cell Rep
. 2021 Oct;
37(4):109889.
PMID: 34706227
Astrocyte-derived cholesterol supports brain cells under physiological conditions. However, in demyelinating lesions, astrocytes downregulate cholesterol synthesis, and the cholesterol that is essential for remyelination has to originate from other cellular...
10.
Butt U, Hassouna I, Garcia-Agudo L, Steixner-Kumar A, Depp C, Barnkothe N, et al.
Int J Mol Sci
. 2021 Apr;
22(6).
PMID: 33804598
We previously introduced the brain erythropoietin (EPO) circle as a model to explain the adaptive 'brain hardware upgrade' and enhanced performance. In this fundamental circle, brain cells, challenged by motor-cognitive...