Constantin Coussios
Overview
Explore the profile of Constantin Coussios including associated specialties, affiliations and a list of published articles.
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29
Citations
513
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Recent Articles
1.
Wu Q, Gray M, Smith C, Bau L, Cleveland R, Coussios C, et al.
J Acoust Soc Am
. 2024 Nov;
156(5):3608-3620.
PMID: 39589331
Both the biological effects and acoustic emissions generated by cavitation are functions of bubble dynamics. Monitoring of acoustic emissions is therefore desirable to improve treatment safety and efficacy. The relationship...
2.
Fuenteslopez C, Gray M, Bahcevanci S, Martin A, Smith C, Coussios C, et al.
Commun Eng
. 2024 Sep;
3(1):129.
PMID: 39251849
Dimethylsulfoxide (DMSO) has conventionally been used for cell cryopreservation both in research and in clinical applications, but has long-term cytotoxic effects. Trehalose, a natural disaccharide, has been proposed as a...
3.
Abbas S, Ceresa C, Hodson L, Nasralla D, Watson C, Mergental H, et al.
Trials
. 2024 Jun;
25(1):386.
PMID: 38886851
Background: Liver disease is the third leading cause of premature death in the UK. Transplantation is the only successful treatment for end-stage liver disease but is limited by a shortage...
4.
Sonosensitive Cavitation Nuclei-A Customisable Platform Technology for Enhanced Therapeutic Delivery
Lyons B, Balkaran J, Dunn-Lawless D, Lucian V, Keller S, OReilly C, et al.
Molecules
. 2023 Dec;
28(23).
PMID: 38067464
Ultrasound-mediated cavitation shows great promise for improving targeted drug delivery across a range of clinical applications. Cavitation nuclei-sound-sensitive constructs that enhance cavitation activity at lower pressures-have become a powerful adjuvant...
5.
Dumbill R, Rabcuka J, Fallon J, Knight S, Hunter J, Voyce D, et al.
Blood
. 2023 Dec;
143(8):721-733.
PMID: 38048591
The volume of oxygen drawn from systemic capillaries down a partial pressure gradient is determined by the oxygen content of red blood cells (RBCs) and their oxygen-unloading kinetics, although the...
6.
Spiers L, Gray M, Lyon P, Sivakumar S, Bekkali N, Scott S, et al.
BMC Cancer
. 2023 Sep;
23(1):896.
PMID: 37741968
Background: The dense stroma of pancreatic ductal adenocarcinomas is a major barrier to drug delivery. To increase the local drug diffusion gradient, high doses of chemotherapeutic agent doxorubicin can be...
7.
Maardalen M, Carlisle R, Coussios C
Pharmaceutics
. 2023 Aug;
15(8).
PMID: 37631324
The promotion of anti-tumour immune responses can be an effective route to the complete remission of primary and metastatic tumours in a small proportion of patients. Hence, researchers are currently...
8.
Chapman W, Barbas A, DAlessandro A, Vianna R, Kubal C, Abt P, et al.
Ann Surg
. 2023 Jun;
278(5):e912-e921.
PMID: 37389552
Objective: To compare conventional low-temperature storage of transplant donor livers [static cold storage (SCS)] with storage of the organs at physiological body temperature [normothermic machine perfusion (NMP)]. Background: The high...
9.
Gray M, Spiers L, Coussios C
Int J Hyperthermia
. 2022 Jul;
39(1):918-934.
PMID: 35853611
Background: PanDox is a Phase-1 trial of chemotherapeutic drug delivery to pancreatic tumors using ultrasound-mediated hyperthermia to release doxorubicin from thermally sensitive liposomes. This report describes trial-related hyperthermia simulations featuring:...
10.
Chaudhry M, Lyon P, Coussios C, Carlisle R
Expert Opin Drug Deliv
. 2022 Jul;
19(8):899-912.
PMID: 35830722
Introduction: Many small molecules and biologic therapeutics have been developed for solid tumor therapy. However, the unique physiology of tumors makes the actual delivery of these drugs into the tumor...