Constantin Blochl
Overview
Explore the profile of Constantin Blochl including associated specialties, affiliations and a list of published articles.
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Articles
22
Citations
145
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Recent Articles
1.
Blochl C, Stork E, Scherer H, Toes R, Wuhrer M, Dominguez-Vega E
Adv Sci (Weinh)
. 2025 Feb;
:e2408769.
PMID: 39985219
Autoantibodies and their post-translational modifications (PTMs) are insightful markers of autoimmune diseases providing diagnostic and prognostic clues, thereby informing clinical decisions. However, current autoantibody analyses focus mostly on IgG1 glycosylation...
2.
Sieberer H, Luciano M, Amend D, Blochl C, Eglseer A, Steinkellner A, et al.
Cell Commun Signal
. 2025 Jan;
23(1):53.
PMID: 39875995
FLT3 mutations occur in approximately 25% of all acute myeloid leukemia (AML) patients. While several FLT3 inhibitors have received FDA approval, their use is currently limited to combination therapies with...
3.
Luciano M, Sieberer H, Krenn P, Dang H, Vetter J, Neuper T, et al.
Cell Commun Signal
. 2024 Sep;
22(1):424.
PMID: 39223663
Background: Acute myeloid leukemia (AML) is characterized by the abnormal proliferation of myeloid precursor cells and presents significant challenges in treatment due to its heterogeneity. Recently, the NLRP3 inflammasome has...
4.
van Schaick G, Wuhrer M, Blochl C, Dolhain R, Dominguez-Vega E
J Proteome Res
. 2024 Jul;
23(7):2431-2440.
PMID: 38965920
Alpha-1-acid glycoprotein (AGP) is a heterogeneous glycoprotein fulfilling key roles in many biological processes, including transport of drugs and hormones and modulation of inflammatory and immune responses. The glycoform profile...
5.
Di Marco F, Hipgrave Ederveen A, van Schaick G, Moran A, Dominguez-Vega E, Nicolardi S, et al.
Carbohydr Polym
. 2024 Jun;
341:122327.
PMID: 38876725
Bacterial pathogens can cause a broad range of infections with detrimental effects on health. Vaccine development is essential as multi-drug resistance in bacterial infections is a rising concern. Recombinantly produced...
6.
Blochl C, Gstottner C, Senard T, Stork E, Scherer H, Toes R, et al.
Anal Chim Acta
. 2023 Oct;
1279:341795.
PMID: 37827688
The conserved region (Fc) of IgG antibodies dictates the interactions with designated receptors thus defining the immunological effector functions of IgG. Amino acid sequence variations in the Fc, recognized as...
7.
Treton G, Sayer C, Schurz M, Jaritsch M, Muller A, Matea C, et al.
J Control Release
. 2023 Aug;
361:694-716.
PMID: 37567507
Extracellular vesicles (EVs) are nanosized intercellular messengers that bear enormous application potential as biological drug delivery vehicles. Much progress has been made for loading or decorating EVs with proteins, peptides...
8.
Di Marco F, Blochl C, Esser-Skala W, Schapertons V, Zhang T, Wuhrer M, et al.
Mol Cell Proteomics
. 2023 Jul;
22(9):100622.
PMID: 37478974
Characterization of highly glycosylated biopharma-ceuticals by mass spectrometry is challenging because of the huge chemical space of coexistent glycoforms present. Here, we report the use of an array of HPLC-mass...
9.
Di Marco F, Blumel G, Blochl C, Wuhrer M, Huber C
Anal Chim Acta
. 2023 Jul;
1274:341574.
PMID: 37455084
Background: Gonadotropins are a class of heavily glycosylated protein hormones, thus extremely challenging to characterize by mass spectrometry. As biopharmaceuticals, gonadotropins are prescribed for the treatment of infertility and are...
10.
Holzner C, Bottinger K, Blochl C, Huber C, Dahms S, Dall E, et al.
Int J Mol Sci
. 2023 Mar;
24(6).
PMID: 36982466
While primarily found in endo-lysosomal compartments, the cysteine protease legumain can also translocate to the cell surface if stabilized by the interaction with the RGD-dependent integrin receptor αVβ3. Previously, it...