Conor Mc Guire
Overview
Explore the profile of Conor Mc Guire including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
899
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0
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Recent Articles
1.
Voet S, Mc Guire C, Hagemeyer N, Martens A, Schroeder A, Wieghofer P, et al.
Nat Commun
. 2018 May;
9(1):2036.
PMID: 29789522
Microglia, the mononuclear phagocytes of the central nervous system (CNS), are important for the maintenance of CNS homeostasis, but also critically contribute to CNS pathology. Here we demonstrate that the...
2.
Devos M, Gilbert B, Denecker G, Leurs K, Mc Guire C, Lemeire K, et al.
J Invest Dermatol
. 2016 Oct;
137(2):494-505.
PMID: 27725202
Unlike its family member p53, TP63 is rarely mutated in human cancer. However, ΔNp63α protein levels are often elevated in tumors of epithelial origin, such as squamous cell carcinoma and...
3.
Maelfait J, Roose K, Vereecke L, Mc Guire C, Sze M, Schuijs M, et al.
PLoS Pathog
. 2016 Jan;
12(1):e1005410.
PMID: 26815999
A20 negatively regulates multiple inflammatory signalling pathways. We here addressed the role of A20 in club cells (also known as Clara cells) of the bronchial epithelium in their response to...
4.
Slowicka K, Vereecke L, Mc Guire C, Sze M, Maelfait J, Kolpe A, et al.
Eur J Immunol
. 2015 Dec;
46(4):971-80.
PMID: 26677802
Optineurin (OPTN) is an evolutionary conserved and ubiquitously expressed ubiquitin-binding protein that has been implicated in glaucoma, Paget bone disease, amyotrophic lateral sclerosis, and other neurodegenerative diseases. From in vitro...
5.
Vereecke L, Vieira-Silva S, Billiet T, van Es J, Mc Guire C, Slowicka K, et al.
Nat Commun
. 2014 Oct;
5:5103.
PMID: 25267258
The transcription factor NF-κB is indispensable for intestinal immune homeostasis, but contributes to chronic inflammation and inflammatory bowel disease (IBD). A20, an inhibitor of both NF-κB and apoptotic signalling, was...
6.
Mc Guire C, Elton L, Wieghofer P, Staal J, Voet S, Demeyer A, et al.
J Neuroinflammation
. 2014 Jul;
11:124.
PMID: 25043939
Background: The paracaspase mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) is crucial for lymphocyte activation through signaling to the transcription factor NF-κB. Besides functioning as a scaffold signaling protein,...
7.
Mc Guire C, Prinz M, Beyaert R, van Loo G
Trends Mol Med
. 2013 Sep;
19(10):604-13.
PMID: 24007818
The nuclear factor kappa B (NF-κB) signaling cascade plays a critical role in the regulation of immune and inflammatory responses and has been implicated in the pathogenesis of autoimmune demyelinating...
8.
Mc Guire C, Wieghofer P, Elton L, Muylaert D, Prinz M, Beyaert R, et al.
J Immunol
. 2013 Feb;
190(6):2896-903.
PMID: 23401595
The paracaspase MALT 1 is a major player in lymphocyte activation and proliferation. MALT1 mediates Ag-induced signaling to the transcription factor NF-κB by functioning both as a scaffold protein and...
9.
Vandenbroucke R, Dejonckheere E, Van Lint P, Demeestere D, Van Wonterghem E, Vanlaere I, et al.
J Neurosci
. 2012 Jul;
32(29):9805-16.
PMID: 22815495
Systemic inflammatory response syndrome (SIRS) is a highly mortal inflammatory disease, associated with systemic inflammation and organ dysfunction. SIRS can have a sterile cause or can be initiated by an...
10.
Mc Guire C, Beyaert R, van Loo G
Trends Neurosci
. 2011 Oct;
34(12):619-28.
PMID: 21999927
Death receptors (DRs) are members of the tumor necrosis factor receptor (TNF-R) superfamily that are characterised by the presence of a conserved intracellular death domain and are able to trigger...