Connor J Cooper
Overview
Explore the profile of Connor J Cooper including associated specialties, affiliations and a list of published articles.
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21
Citations
359
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Recent Articles
1.
Leus I, Weeks J, Bonifay V, Shen Y, Yang L, Cooper C, et al.
Sci Rep
. 2023 Jun;
13(1):8918.
PMID: 37264107
No abstract available.
2.
Sanders B, Pokhrel S, Labbe A, Mathews I, Cooper C, Davidson R, et al.
Nat Commun
. 2023 Mar;
14(1):1733.
PMID: 36977673
Direct-acting antivirals are needed to combat coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). The papain-like protease (PLpro) domain of Nsp3 from SARS-CoV-2 is essential...
3.
Moniruzzaman M, Cooper C, Uddin M, Walker J, Parks J, Zgurskaya H
ACS Infect Dis
. 2022 Sep;
8(10):2149-2160.
PMID: 36070489
Optimization of compound permeation into Gram-negative bacteria is one of the most challenging tasks in the development of antibacterial agents. Two permeability barriers─the passive diffusion barrier of the outer membrane...
4.
Leus I, Weeks J, Bonifay V, Shen Y, Yang L, Cooper C, et al.
Sci Rep
. 2022 May;
12(1):8220.
PMID: 35581346
Two membrane cell envelopes act as selective permeability barriers in Gram-negative bacteria, protecting cells against antibiotics and other small molecules. Significant efforts are being directed toward understanding how small molecules...
5.
Semchonok D, Mondal J, Cooper C, Schlum K, Li M, Amin M, et al.
Plant Commun
. 2022 Jan;
3(1):100248.
PMID: 35059628
Photosystem I (PSI) is one of two photosystems involved in oxygenic photosynthesis. PSI of cyanobacteria exists in monomeric, trimeric, and tetrameric forms, in contrast to the strictly monomeric form of...
6.
Gumbart J, Ferreira J, Hwang H, Hazel A, Cooper C, Parks J, et al.
Biophys J
. 2021 Aug;
120(18):3973-3982.
PMID: 34411576
The multidrug efflux pumps of Gram-negative bacteria are a class of complexes that span the periplasm, coupling both the inner and outer membranes to expel toxic molecules. The best-characterized example...
7.
DCunha N, Moniruzzaman M, Haynes K, Malloci G, Cooper C, Margiotta E, et al.
ACS Infect Dis
. 2021 Aug;
7(9):2650-2665.
PMID: 34379382
Antibiotic resistance poses an immediate and growing threat to human health. Multidrug efflux pumps are promising targets for overcoming antibiotic resistance with small-molecule therapeutics. Previously, we identified a diaminoquinoline acrylamide,...
8.
Lian P, Mou Z, Cooper C, Johnston R, Brooks S, Gu B, et al.
J Phys Chem A
. 2021 Jun;
125(24):5397-5405.
PMID: 34114820
Mercury (Hg) pollution is a global environmental problem. The abiotic formation of dimethylmercury (DMeHg) from monomethylmercury (MMeHg) may account for a large portion of DMeHg in oceans. Previous experimental work...
9.
Mishra S, Cooper C, Parks J, Mitchell J
J Phys Chem B
. 2021 Jun;
125(23):6058-6067.
PMID: 34077660
Protein-protein interactions play a key role in mediating numerous biological functions, with more than half the proteins in living organisms existing as either homo- or hetero-oligomeric assemblies. Protein subunits that...
10.
Ajina R, Malchiodi Z, Fitzgerald A, Zuo A, Wang S, Moussa M, et al.
Cancer Immunol Res
. 2021 Jan;
9(4):386-400.
PMID: 33509790
Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer death in the United States. Pancreatic tumors are minimally infiltrated by T cells and are largely refractory to immunotherapy....