Collin Melton
Overview
Explore the profile of Collin Melton including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
1741
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0
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Recent Articles
1.
Bosse Y, Dasgupta A, Abadier M, Guthrie V, Song F, Armero V, et al.
Cancer Lett
. 2024 May;
594:216984.
PMID: 38797230
Background: Circulating tumor DNA (ctDNA) positivity at diagnosis, which is associated with worse outcomes in multiple solid tumors including stage I-III non-small cell lung cancer (NSCLC), may have utility to...
2.
Jamshidi A, Liu M, Klein E, Venn O, Hubbell E, Beausang J, et al.
Cancer Cell
. 2022 Nov;
40(12):1537-1549.e12.
PMID: 36400018
In the Circulating Cell-free Genome Atlas (NCT02889978) substudy 1, we evaluate several approaches for a circulating cell-free DNA (cfDNA)-based multi-cancer early detection (MCED) test by defining clinical limit of detection...
3.
Chen X, Dong Z, Hubbell E, Kurtzman K, Oxnard G, Venn O, et al.
Clin Cancer Res
. 2021 Jun;
27(15):4221-4229.
PMID: 34088722
Purpose: We recently reported the development of a cell-free DNA (cfDNA) targeted methylation (TM)-based sequencing approach for a multi-cancer early detection (MCED) test that includes cancer signal origin prediction. Here,...
4.
Zhang W, Bojorquez-Gomez A, Ortiz Velez D, Xu G, Sanchez K, Shen J, et al.
Nat Genet
. 2018 Apr;
50(4):613-620.
PMID: 29610481
Although cancer genomes are replete with noncoding mutations, the effects of these mutations remain poorly characterized. Here we perform an integrative analysis of 930 tumor whole genomes and matched transcriptomes,...
5.
Wang E, Reyes N, Melton C, Huskey N, Momcilovic O, Goga A, et al.
Curr Biol
. 2015 Nov;
25(23):3110-8.
PMID: 26585277
The intrinsic (mitochondrial) apoptotic pathway is a conserved cell death program crucial for eliminating superfluous, damaged, or incorrectly specified cells, and the multi-domain pro-death BCL-2 family proteins BAX and BAK...
6.
Melton C, Reuter J, Spacek D, Snyder M
Nat Genet
. 2015 Jun;
47(7):710-6.
PMID: 26053494
Aberrant regulation of gene expression in cancer can promote survival and proliferation of cancer cells. Here we integrate whole-genome sequencing data from The Cancer Genome Atlas (TCGA) for 436 patients...
7.
Wang Y, Melton C, Li Y, Shenoy A, Zhang X, Subramanyam D, et al.
Cell Rep
. 2013 Jul;
4(1):99-109.
PMID: 23831024
The miR-294 and miR-302 microRNAs promote the abbreviated G1 phase of the embryonic stem cell (ESC) cell cycle and suppress differentiation induced by let-7. Here, we evaluated the role of...
8.
Babiarz J, Hsu R, Melton C, Thomas M, Ullian E, Blelloch R
RNA
. 2011 Jun;
17(8):1489-501.
PMID: 21712401
Noncanonical microRNAs (miRNAs) and endogenous small interfering RNAs (endo-siRNAs) are distinct subclasses of small RNAs that bypass the DGCR8/DROSHA Microprocessor but still require DICER1 for their biogenesis. What role, if...
9.
Chen J, Melton C, Suh N, Oh J, Horner K, Xie F, et al.
Genes Dev
. 2011 Apr;
25(7):755-66.
PMID: 21460039
Oocyte maturation, fertilization, and early embryonic development occur in the absence of gene transcription. Therefore, it is critical to understand at a global level the post-transcriptional events that are driving...
10.
Melton C, Blelloch R
Adv Exp Med Biol
. 2011 Jan;
695:105-17.
PMID: 21222202
Stem cell differentiation requires a complex coordination of events to transition from a self-renewing to a differentiated cell fate. Stem cells can be pluripotent (capable of giving rise to all...