Colleen M Noviello
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Explore the profile of Colleen M Noviello including associated specialties, affiliations and a list of published articles.
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21
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1231
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Recent Articles
1.
Zhou J, Noviello C, Teng J, Moore H, Lega B, Hibbs R
Nature
. 2025 Jan;
638(8050):562-568.
PMID: 39843743
Type A GABA (γ-aminobutyric acid) receptors (GABA receptors) mediate most fast inhibitory signalling in the brain and are targets for drugs that treat epilepsy, anxiety, depression and insomnia and for...
2.
Baxter L, Hopkins S, OConnor K, Pham M, Nowak R, Monson N, et al.
J Neuroimmunol
. 2024 Sep;
396:578454.
PMID: 39277987
Autoimmune autonomic ganglionopathy (AAG) is a rare disease wherein autoantibodies target the ganglionic acetylcholine receptor (gAChR). Current diagnosis in the United States depends upon clinical symptoms and positive autoantibody detection...
3.
Noviello C
Sci Immunol
. 2024 Sep;
9(99):eads7642.
PMID: 39241055
IL-10 autoantibodies are detected in two patients with severe inflammatory bowel disease.
4.
Burke S, Avstrikova M, Noviello C, Mukhtasimova N, Changeux J, Thakur G, et al.
Cell
. 2024 Feb;
187(5):1160-1176.e21.
PMID: 38382524
The α7 nicotinic acetylcholine receptor is a pentameric ligand-gated ion channel that plays an important role in cholinergic signaling throughout the nervous system. Its unique physiological characteristics and implications in...
5.
Legesse D, Fan C, Teng J, Zhuang Y, Howard R, Noviello C, et al.
Nat Commun
. 2023 Aug;
14(1):5091.
PMID: 37607940
γ-Aminobutyric acid type A (GABA) receptors mediate fast inhibitory signaling in the brain and are targets of numerous drugs and endogenous neurosteroids. A subset of neurosteroids are GABA receptor positive...
6.
Zhuang Y, Noviello C, Hibbs R, Howard R, Lindahl E
Proc Natl Acad Sci U S A
. 2022 Oct;
119(43):e2208081119.
PMID: 36251999
The α7 nicotinic acetylcholine receptor is a pentameric ligand-gated ion channel that modulates neuronal excitability, largely by allowing Ca permeation. Agonist binding promotes transition from a resting state to an...
7.
Noviello C, Kreye J, Teng J, Pruss H, Hibbs R
Cell
. 2022 Jul;
185(14):2469-2477.e13.
PMID: 35803245
Autoantibodies targeting neuronal membrane proteins can cause encephalitis, seizures, and severe behavioral abnormalities. While antibodies for several neuronal targets have been identified, structural details on how they regulate function are...
8.
Noviello C, Gharpure A, Mukhtasimova N, Cabuco R, Baxter L, Borek D, et al.
Cell
. 2021 Mar;
184(8):2121-2134.e13.
PMID: 33735609
The α7 nicotinic acetylcholine receptor plays critical roles in the central nervous system and in the cholinergic inflammatory pathway. This ligand-gated ion channel assembles as a homopentamer, is exceptionally permeable...
9.
Kim J, Gharpure A, Teng J, Zhuang Y, Howard R, Zhu S, et al.
Nature
. 2020 Sep;
585(7824):303-308.
PMID: 32879488
Most general anaesthetics and classical benzodiazepine drugs act through positive modulation of γ-aminobutyric acid type A (GABA) receptors to dampen neuronal activity in the brain. However, direct structural information on...
10.
Rahman M, Teng J, Worrell B, Noviello C, Lee M, Karlin A, et al.
Neuron
. 2020 Apr;
106(6):952-962.e5.
PMID: 32275860
The nicotinic acetylcholine receptor, a pentameric ligand-gated ion channel, converts the free energy of binding of the neurotransmitter acetylcholine into opening of its central pore. Here we present the first...