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Colin I Johnston

Explore the profile of Colin I Johnston including associated specialties, affiliations and a list of published articles. Areas
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Articles 29
Citations 2112
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21.
Burrell L, Risvanis J, Kubota E, Dean R, Macdonald P, Lu S, et al.
Eur Heart J . 2005 Jan; 26(4):369-75. PMID: 15671045
Aims: Angiotensin converting enzyme (ACE) 2 catalyses the cleavage of angiotensin (Ang) I to Ang 1-9 and of Ang II to Ang 1-7. ACE2 deficiency impairs cardiac contractility and upregulates...
22.
Burrell L, Johnston C, Tikellis C, Cooper M
Trends Endocrinol Metab . 2004 Apr; 15(4):166-9. PMID: 15109615
Angiotensin-converting enzyme (ACE) is a zinc metalloproteinase and a key regulator of the renin-angiotensin system (RAS). ACE2 is a newly described enzyme identified in rodents and humans with a more...
23.
Kubota E, Dean R, Hubner R, Casley D, Johnston C, Burrell L
Clin Sci (Lond) . 2003 May; 105(3):339-45. PMID: 12741953
Vasopeptidase inhibitors simultaneously inhibit angiotensin-converting enzyme (ACE) and neutral endopeptidase (NEP). The present study characterized the tissue distributions of ACE and NEP, and assessed the effects of the vasopeptidase inhibitor...
24.
Fabiani M, Hawkes D, Frauman A, Tikellis C, Johnston C, Wilkinson-Berka J
Int J Biochem Cell Biol . 2003 Apr; 35(6):973-83. PMID: 12676181
We examined the regulation/expression of angiotensin II (Ang II) receptors in the transgenic (TG) (mRen-2)27 rat compared to the normal Sprague-Dawley (SD) rat. Ang II receptor binding and mRNA expression...
25.
Tikellis C, Johnston C, Forbes J, Burns W, Burrell L, Risvanis J, et al.
Hypertension . 2003 Mar; 41(3):392-7. PMID: 12623933
ACE2, initially cloned from a human heart, is a recently described homologue of angiotensin-converting enzyme (ACE) but contains only a single enzymatic site that catalyzes the cleavage of angiotensin I...
26.
Wing L, Reid C, Ryan P, Beilin L, Brown M, Jennings G, et al.
N Engl J Med . 2003 Feb; 348(7):583-92. PMID: 12584366
Background: Treatment of hypertension with diuretics, beta-blockers, or both leads to improved outcomes. It has been postulated that agents that inhibit the renin-angiotensin system confer benefit beyond the reduction of...
27.
Naitoh M, Risvanis J, Balding L, Johnston C, Burrell L
Cardiovasc Res . 2002 Jun; 54(1):51-7. PMID: 12062361
Objective: To assess the long-term efficacy of vasopressin (AVP) V(1a) and V(2) receptor blockade with conivaptan, alone and in combination with angiotensin converting enzyme (ACE) inhibition on blood pressure, metabolic...
28.
Tikkanen I, Tikkanen T, Cao Z, Allen T, Davis B, Lassila M, et al.
J Hypertens . 2002 Mar; 20(4):707-14. PMID: 11910307
Objective: The effects of combined inhibition of neutral endopeptidase (NEP) with either angiotensin-converting enzyme (ACE), or endothelin-converting enzyme (ECE) on blood pressure, urinary albumin excretion and heart weight were explored...
29.
Dinh D, Frauman A, Somers G, Ohishi M, Zhou J, Casley D, et al.
J Pathol . 2002 Jan; 196(2):213-9. PMID: 11793373
The expression and cellular localization of angiotensin II (Ang II) and AT(1) receptor proteins were examined in the normal human prostate and benign prostatic hyperplasia (BPH) by immunohistochemistry. In the...