Claudia Spits
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Explore the profile of Claudia Spits including associated specialties, affiliations and a list of published articles.
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44
Citations
1036
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Recent Articles
11.
Neves A, Garcia S, Vuong L, Blockeel C, Arroyo G, Spits C, et al.
Reprod Biomed Online
. 2023 May;
46(5):826-834.
PMID: 37130623
Research Question: Is there an association between FSHR sequence variants and reproductive outcomes following IVF in predicted normoresponders? Design: Multicentre prospective cohort study conducted from November 2016 to June 2019...
12.
Andrews P, Barbaric I, Benvenisty N, Draper J, Ludwig T, Merkle F, et al.
Cell Stem Cell
. 2022 Dec;
29(12):1624-1636.
PMID: 36459966
It is well established that human pluripotent stem cells (hPSCs) can acquire genetic and epigenetic changes during culture in vitro. Given the increasing use of hPSCs in research and therapy...
13.
De Rycke M, Capalbo A, Coonen E, Coticchio G, Fiorentino F, Goossens V, et al.
Hum Reprod Open
. 2022 Nov;
2022(4):hoac044.
PMID: 36349144
Study Question: How should ART/preimplantation genetic testing (PGT) centres manage the detection of chromosomal mosaicism following PGT? Summary Answer: Thirty good practice recommendations were formulated that can be used by...
14.
Keller A, Krivec N, Markouli C, Spits C
Methods Mol Biol
. 2022 May;
2429:57-72.
PMID: 35507155
Human pluripotent stem cells have a wide variety of potential applications, ranging from clinical translation to in vitro disease modeling. However, there is significant variation in the potential of individual...
15.
Regin M, Spits C, Sermon K
Mol Hum Reprod
. 2022 Apr;
28(4).
PMID: 35404421
About 8 out of 10 human embryos obtained in vitro harbour chromosomal abnormalities of either meiotic or mitotic origin. Abnormalities of mitotic origin lead to chromosomal mosaicism, a phenomenon that...
16.
Mertens J, Regin M, De Munck N, Couvreu de Deckersberg E, Belva F, Sermon K, et al.
Hum Mol Genet
. 2022 Mar;
31(21):3629-3642.
PMID: 35285472
Humans present remarkable diversity in their mitochondrial DNA (mtDNA) in terms of variants across individuals as well as across tissues and even cells within one person. We have investigated the...
17.
Franck S, Couvreu de Deckersberg E, Bubenik J, Markouli C, Barbe L, Allemeersch J, et al.
Biol Open
. 2022 Jan;
11(1).
PMID: 35019138
Skeletal muscle tissue is severely affected in myotonic dystrophy type 1 (DM1) patients, characterised by muscle weakness, myotonia and muscle immaturity in the most severe congenital form of the disease....
18.
Keller A, Spits C
Cells
. 2021 Nov;
10(11).
PMID: 34831467
Human pluripotent stem cells (hPSC) are known to acquire chromosomal abnormalities, which range from point mutations to large copy number changes, including full chromosome aneuploidy. These aberrations have a wide-ranging...
19.
Dziedzicka D, Tewary M, Keller A, Tilleman L, Prochazka L, Ostblom J, et al.
Sci Rep
. 2021 Mar;
11(1):6137.
PMID: 33731744
Low differentiation propensity towards a targeted lineage can significantly hamper the utility of individual human pluripotent stem cell (hPSC) lines in biomedical applications. Here, we use monolayer and micropatterned cell...
20.
Mertens J, Zambelli F, Daneels D, Caljon B, Sermon K, Spits C
Bio Protoc
. 2021 Mar;
9(13):e3283.
PMID: 33654798
Detecting heteroplasmies in the mitochondrial DNA (mtDNA) has been a challenge for many years. In the past, Sanger sequencing was the main option to perform this analysis, however, this method...