Claudia Muhle-Goll
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Explore the profile of Claudia Muhle-Goll including associated specialties, affiliations and a list of published articles.
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64
Citations
690
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Recent Articles
1.
Weber A, Moser C, Martini M, Lass F, Bleher K, Muhle-Goll C, et al.
Chemistry
. 2025 Jan;
e202404688.
PMID: 39876675
Enantioselectivity is a key advantage of enzymatic catalysis. Understanding the most important factors influencing enantioselectivity necessitates thorough investigation for each specific enzyme. In this study, we explore various approaches to...
2.
Moser C, Guschtschin-Schmidt N, Silber M, Flum J, Muhle-Goll C
ACS Chem Neurosci
. 2024 Jul;
15(15):2956.
PMID: 39007498
No abstract available.
3.
Moser C, Guschtschin-Schmidt N, Silber M, Flum J, Muhle-Goll C
ACS Chem Neurosci
. 2024 Mar;
15(7):1321-1334.
PMID: 38525994
Alzheimer's disease is the most common form of dementia encountered in an aging population. Characteristic amyloid deposits of Aβ peptides in the brain are generated through cleavage of amyloid precursor...
4.
Neeb A, Figueiredo I, Bogdan D, Cato L, Stober J, Jimenez-Vacas J, et al.
Mol Cancer Ther
. 2024 Feb;
23(6):791-808.
PMID: 38412481
Therapies that abrogate persistent androgen receptor (AR) signaling in castration-resistant prostate cancer (CRPC) remain an unmet clinical need. The N-terminal domain of the AR that drives transcriptional activity in CRPC...
5.
Assfalg M, Guner G, Muller S, Breimann S, Langosch D, Muhle-Goll C, et al.
FASEB J
. 2024 Jan;
38(2):e23442.
PMID: 38275103
The intramembrane protease γ-secretase has broad physiological functions, but also contributes to Notch-dependent tumors and Alzheimer's disease. While γ-secretase cleaves numerous membrane proteins, only few nonsubstrates are known. Thus, a...
6.
Moser C, Muhle-Goll C
Protein Expr Purif
. 2023 Nov;
215:106407.
PMID: 38000778
Cleavage of the transmembrane domain (TMD) of amyloid-β precursor protein (APP) by γ-secretase, an intramembrane aspartyl protease, generates Aβ peptides of various lengths that form plaques in the brains of...
7.
Ortner M, Guschtschin-Schmidt N, Stelzer W, Muhle-Goll C, Langosch D
J Mol Biol
. 2023 Aug;
435(18):168218.
PMID: 37536392
The intramembrane protease γ-secretase activates important signaling molecules, such as Notch receptors. It is still unclear, however, how different elements within the primary structure of substrate transmembrane domains (TMDs) contribute...
8.
Papadopoulou A, Stelzer W, Silber M, Schlosser C, Spitz C, Haug-Kroper M, et al.
Sci Rep
. 2022 Dec;
12(1):20987.
PMID: 36470941
Signal-Peptide Peptidase Like-3 (SPPL3) is an intramembrane cleaving aspartyl protease that causes secretion of extracellular domains from type-II transmembrane proteins. Numerous Golgi-localized glycosidases and glucosyltransferases have been identified as physiological...
9.
Hollenbach R, Delavault A, Gebhardt L, Soergel H, Muhle-Goll C, Ochsenreither K, et al.
ACS Sustain Chem Eng
. 2022 Aug;
10(31):10192-10202.
PMID: 35966390
Mechanochemical and biocatalytic approaches in modern research are two major assets to develop greener processes. In the present study, these modular tools of sustainability are pointed toward the production of...
10.
Siebert V, Silber M, Heuten E, Muhle-Goll C, Lemberg M
J Biol Chem
. 2022 Aug;
298(9):102321.
PMID: 35921890
The intramembrane protease PARL acts as a crucial mitochondrial safeguard by cleaving the mitophagy regulators PINK1 and PGAM5. Depending on the stress level, PGAM5 can either stimulate cell survival or...