Claudia A McCarthy
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Explore the profile of Claudia A McCarthy including associated specialties, affiliations and a list of published articles.
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11
Citations
391
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Recent Articles
1.
Knezic A, Budusan E, Saez N, Broughton B, Rash L, King G, et al.
ACS Pharmacol Transl Sci
. 2024 Apr;
7(4):1043-1054.
PMID: 38638162
Activation of acid-sensing ion channel 1a (ASIC1a) plays a major role in mediating acidosis-induced neuronal injury following a stroke. Therefore, the inhibition of ASIC1a is a potential therapeutic avenue for...
2.
Knezic A, Broughton B, Widdop R, McCarthy C
Sci Rep
. 2022 May;
12(1):7598.
PMID: 35534531
The photothrombotic stroke model relies on the interaction between photosensitive-dye and light for clot formation. Interestingly, the relationship between the length of light exposure and stroke-outcome has never been examined....
3.
Chassagnon I, McCarthy C, Chin Y, Pineda S, Keramidas A, Mobli M, et al.
Proc Natl Acad Sci U S A
. 2017 Mar;
114(14):3750-3755.
PMID: 28320941
Stroke is the second-leading cause of death worldwide, yet there are no drugs available to protect the brain from stroke-induced neuronal injury. Acid-sensing ion channel 1a (ASIC1a) is the primary...
4.
McCarthy C, Rash L, Chassagnon I, King G, Widdop R
Neuropharmacology
. 2015 Sep;
99:650-7.
PMID: 26320544
Acid-sensing ion channel 1a (ASIC1a) is the primary acid sensor in mammalian brain and plays a major role in neuronal injury following cerebral ischemia. Evidence that inhibition of ASIC1a might...
5.
McCarthy C, Facey L, Widdop R
Curr Hypertens Rep
. 2014 May;
16(7):440.
PMID: 24816974
It is quite well established that activation of the so-called protective arms of the renin-angiotensin system (RAS), involving both AT2 and Mas receptors, provides a counter-regulatory role to AT1 receptor...
6.
McCarthy C, Vinh A, Miller A, Hallberg A, Alterman M, Callaway J, et al.
PLoS One
. 2014 Apr;
9(4):e95762.
PMID: 24752645
Background: In this study, the neuroprotective effect of a novel nonpeptide AT2R agonist, C21, was examined in a conscious model of stroke to verify a class effect of AT2R agonists...
7.
McCarthy C, Widdop R, Deliyanti D, Wilkinson-Berka J
Clin Exp Pharmacol Physiol
. 2013 Apr;
40(8):571-9.
PMID: 23601050
Microglia are the resident immune cells within the brain and retina, commonly known as the macrophages of the central nervous system (CNS). Microglia survey the surrounding milieu to eliminate invading...
8.
McCarthy C, Widdop R, Denton K, Jones E
Curr Hypertens Rep
. 2012 Dec;
15(1):25-30.
PMID: 23224511
It is quite well established that activation of the AT(2) receptor (AT(2)R) provides a counter-regulatory role to AT(1)R overactivity, particularly during pathological conditions. Indeed, a potential therapeutic role for the...
9.
McCarthy C, Vinh A, Broughton B, Sobey C, Callaway J, Widdop R
Hypertension
. 2012 Oct;
60(6):1531-7.
PMID: 23090772
We have demonstrated previously that pretreatment with an angiotensin II type 2 receptor (AT(2)R) agonist is neuroprotective against a subsequent stroke independent of any changes in blood pressure. Therefore, in...
10.
McCarthy C, Vinh A, Callaway J, Widdop R
Stroke
. 2009 Feb;
40(4):1482-9.
PMID: 19246705
Background And Purpose: The angiotensin II type 2 receptor (AT(2)R) is implicated to be neuroprotective in stroke, although this premise has not been directly tested. Therefore, we have examined the...