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Clare K Underwood

Explore the profile of Clare K Underwood including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 8
Citations 277
Followers 0
Related Specialties
Neurology
Cell Biology
Biochemistry
Top 10 Co-Authors
Elizabeth J Coulson
Perry F Bartlett
Kate Reid
Tim J Butler
Linda M May
Areechun Sotthibundhu
Paul J Taylor
Sune Skeldal
Matthew D Hall
Pankaj Sah
Published In
J Neurosci
J Inorg Biochem
Mol Cell Neurosci
J Cell Sci
J Neurochem
Affiliations
Soon will be listed here.
Recent Articles
1.
Inhibition of motor neuron death in vitro and in vivo by a p75 neurotrophin receptor intracellular domain fragment
Matusica D, Alfonsi F, Turner B, Butler T, Shepheard S, Rogers M, et al.
J Cell Sci . 2015 Oct; 129(3):517-30. PMID: 26503157
The p75 neurotrophin receptor (p75(NTR); also known as NGFR) can mediate neuronal apoptosis in disease or following trauma, and facilitate survival through interactions with Trk receptors. Here we tested the...
2.
Non-invasive diffusion tensor imaging detects white matter degeneration in the spinal cord of a mouse model of amyotrophic lateral sclerosis
Underwood C, Kurniawan N, Butler T, Cowin G, Wallace R
Neuroimage . 2010 Dec; 55(2):455-61. PMID: 21185943
Amyotrophic lateral sclerosis (ALS) is characterized by selective degeneration of motor neurons. Here we examine the ability of magnetic resonance imaging (MRI) to measure axonal degeneration in the lumbar spinal...
3.
Beta-amyloid(1-42) induces neuronal death through the p75 neurotrophin receptor
Sotthibundhu A, Sykes A, Fox B, Underwood C, Thangnipon W, Coulson E
J Neurosci . 2008 Apr; 28(15):3941-6. PMID: 18400893
Alzheimer's disease is characterized by the accumulation of neurotoxic amyloidogenic peptide Abeta, degeneration of the cholinergic innervation to the hippocampus (the septohippocampal pathway), and progressive impairment of cognitive function, particularly...
4.
p75 neurotrophin receptor mediates neuronal cell death by activating GIRK channels through phosphatidylinositol 4,5-bisphosphate
Coulson E, May L, Osborne S, Reid K, Underwood C, Meunier F, et al.
J Neurosci . 2008 Jan; 28(1):315-24. PMID: 18171948
The pan neurotrophin receptor p75(NTR) signals programmed cell death both during nervous system development and after neural trauma and disease in the adult. However, the molecular pathways by which death...
5.
Palmitoylation of the C-terminal fragment of p75(NTR) regulates death signaling and is required for subsequent cleavage by gamma-secretase
Underwood C, Reid K, May L, Bartlett P, Coulson E
Mol Cell Neurosci . 2007 Dec; 37(2):346-58. PMID: 18055214
It has recently been shown that the p75 neurotrophin receptor (p75(NTR)), which is known to mediate neural cell death during development of the nervous system and in a range of...
6.
The p75 neurotrophin receptor
Underwood C, Coulson E
Int J Biochem Cell Biol . 2007 Aug; 40(9):1664-8. PMID: 17681869
The pan neurotrophin receptor (p75(NTR)) is best known for mediating neural cell death during development as well as in the adult following injury, the latter making it a target for...
7.
Copper induced oxidation of serotonin: analysis of products and toxicity
Jones C, Underwood C, Coulson E, Taylor P
J Neurochem . 2007 Aug; 102(4):1035-43. PMID: 17663749
Serotonin is a major neurotransmitter that controls many functions, ranging from mood and behaviour through to sleep and motor functions. The non-enzymatic oxidation of serotonin is of significant importance as...
8.
XANES investigation of the Co oxidation state in solution and in cancer cells treated with Co(III) complexes
Bonnitcha P, Hall M, Underwood C, Foran G, Zhang M, Beale P, et al.
J Inorg Biochem . 2006 Apr; 100(5-6):963-71. PMID: 16624414
XANES spectroscopy has been used to investigate whether it is possible to determine the oxidation state and coordination environment of Co complexes following treatment of cancer cells with Co(III) or...