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Claire N Hoffman

Explore the profile of Claire N Hoffman including associated specialties, affiliations and a list of published articles. Areas
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Recent Articles
1.
Jimenez-Harrison D, Huseby C, Hoffman C, Sher S, Snyder D, Seal B, et al.
Biochemistry . 2023 Feb; 62(5):976-988. PMID: 36813261
Tau aggregate-bearing lesions are pathological markers and potential mediators of tauopathic neurodegenerative diseases, including Alzheimer's disease. The molecular chaperone DJ-1 colocalizes with tau pathology in these disorders, but it has...
2.
Huseby C, Hoffman C, Cooper G, Cocuron J, Alonso A, Thomas S, et al.
J Alzheimers Dis . 2019 Aug; 71(3):979-991. PMID: 31450505
Tau is a microtubule-associated protein that normally interacts in monomeric form with the neuronal cytoskeleton. In Alzheimer's disease, however, it aggregates to form the structural component of neurofibrillary lesions. The...
3.
Headley C, Hoffman C, Freisen J, Han Y, Macklin J, Zweier J, et al.
Org Biomol Chem . 2019 Jul; 17(33):7694-7705. PMID: 31328213
Membranous organelles are major endogenous sources of reactive oxygen and nitrogen species. When present at high levels, these species can cause macromolecular damage and disease. To better detect and scavenge...