Chwen-Ming Shih
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Explore the profile of Chwen-Ming Shih including associated specialties, affiliations and a list of published articles.
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63
Citations
5825
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Recent Articles
1.
Kuo Y, Ho K, Shih C, Chen P, Liu A, Chen K
Life Sci
. 2022 Oct;
309:121023.
PMID: 36202175
Aims: Glioblastoma multiforme (GBM) is the most aggressive and mortal primary glioma in adults. Temozolomide (TMZ) is a first-line clinical chemotherapeutic drug. However, TMZ resistance causes treatment failure in patients....
2.
Ho K, Shih C, Liu A, Chen K
Cancer Sci
. 2021 Dec;
113(2):540-552.
PMID: 34897892
An insufficient oxygen supply within the intratumoral environment, also known as hypoxia, induces glioblastoma multiforme (GBM) invasion, stemness, and temozolomide (TMZ) drug resistance. Long noncoding (lnc)RNAs have been reported to...
3.
Ho K, Huang T, Liu A, Shih C, Chen K
Cancers (Basel)
. 2021 Apr;
13(9).
PMID: 33924966
: Heterogeneous features of lung adenocarcinoma (LUAD) are used to stratify patients into terminal respiratory unit (TRU), proximal-proliferative (PP), and proximal-inflammatory (PI) subtypes. A more-accurate subtype classification would be helpful...
4.
Lee C, Ho K, Huang T, Shih C, Hsu S, Liu A, et al.
Life Sci
. 2021 Apr;
277:119438.
PMID: 33798549
Aims: Immune checkpoints regulate immunity to prevent autoimmunity and protect the host from damage during pathogenic infection. They also participate in subverting immune surveillance and promote antitumor immunity in cancers....
5.
Ho K, Huang T, Shih C, Lee Y, Liu A, Chen P, et al.
BMC Med
. 2021 Feb;
19(1):59.
PMID: 33627136
Background: Long noncoding (lnc)RNAs and glycolysis are both recognized as key regulators of cancers. Some lncRNAs are also reportedly involved in regulating glycolysis metabolism. However, glycolysis-associated lncRNA signatures and their...
6.
Ho K, Lee Y, Chen P, Shih C, Cheng C, Chen K
Neurotherapeutics
. 2021 Jan;
18(2):1371-1392.
PMID: 33410111
Limited therapeutic efficacy of temozolomide (TMZ) against glioblastomas highlights the importance of exploring new drugs for clinical therapy. Sunitinib, a multitargeted receptor tyrosine kinase inhibitor, is currently being tested as...
7.
Ho K, Chen P, Shih C, Lee Y, Cheng C, Liu A, et al.
Cell Mol Neurobiol
. 2020 Oct;
42(3):791-806.
PMID: 33025417
The insulin-like growth factor (IGF)-1 and transforming growth factor (TGF)-β signal pathways are both recognized as important in regulating cancer prognosis, such as the epithelial-to-mesenchymal transition (EMT) and cell invasion....
8.
Ho K, Kuo T, Lee Y, Chen P, Shih C, Cheng C, et al.
Life Sci
. 2020 May;
254:117807.
PMID: 32422304
Aims: Xanthohumol (XN), a natural prenylated flavonoid isolated from Humulus lupulus L. (hops), possess the therapeutic effects in glioblastoma multiforme (GBM), which is a grade IV aggressive glioma in adults....
9.
Ho K, Chen P, Chou C, Shih C, Lee Y, Cheng C, et al.
Neurotherapeutics
. 2020 Jan;
17(3):1212-1227.
PMID: 31916238
DNA damage-inducible transcript 4 (DDIT4) is known to participate in various cancers, including glioblastoma multiforme (GBM). However, contradictory roles of DDIT4 exist in inducing cell death and possessing anti-apoptotic functions...
10.
Chen K, Chen P, Ho K, Shih C, Chou C, Cheng C, et al.
PLoS One
. 2019 Dec;
14(12):e0225913.
PMID: 31805126
Temozolomide (TMZ) is a first-line alkylating agent for glioblastoma multiforme (GBM). Clarifying the mechanisms inducing TMZ insensitivity may be helpful in improving its therapeutic effectiveness against GBM. Insulin-like growth factor...