Chunlei Cang
Overview
Explore the profile of Chunlei Cang including associated specialties, affiliations and a list of published articles.
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Articles
26
Citations
849
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Recent Articles
1.
Huang Y, Lu H, Liu Y, Wang J, Xia Q, Shi X, et al.
EMBO J
. 2025 Jan;
44(5):1414-1441.
PMID: 39875724
mTOR plays a pivotal role in cancer growth control upon amino acid response. Recently, CDK inhibitor P27KIP1 has been reported as a noncanonical inhibitor of mTOR signaling in MEFs, via...
2.
Zeng W, Li C, Qu L, Cang C
Autophagy
. 2024 Aug;
20(11):2591-2592.
PMID: 39147379
Lysosomes are essential degradative organelles and signaling hubs within cells, playing a crucial role in the regulation of macroautophagy/autophagy. Dysfunction of lysosomes and impaired autophagy are closely associated with the...
3.
Wu Y, Huang J, Zhang F, Guivel-Benhassine F, Hubert M, Schwartz O, et al.
FEBS J
. 2024 Aug;
291(18):4142-4154.
PMID: 39097908
DABMA is a chemical molecule optimized from the parent compound ABMA and exhibits broad-spectrum antipathogenic activity by modulating the host's endolysosomal and autophagic pathways. Both DABMA and ABMA inhibit severe...
4.
Dai M, Lin B, Li H, Wang Y, Wu M, Wei Y, et al.
Mol Cell Biochem
. 2024 Jul;
480(2):1209-1224.
PMID: 38951379
Despite the implementation of novel therapeutic regimens and extensive research efforts, chemoresistance remains a formidable challenge in the treatment of acute myeloid leukemia (AML). Notably, the involvement of lysosomes in...
5.
Inhibition of lysosomal TRPML1 channel eliminates breast cancer stem cells by triggering ferroptosis
Fan C, Wu H, Du X, Li C, Zeng W, Qu L, et al.
Cell Death Discov
. 2024 May;
10(1):256.
PMID: 38802335
Cancer stem cells (CSCs) are a sub-population of cells possessing high tumorigenic potential, which contribute to therapeutic resistance, metastasis and recurrence. Eradication of CSCs is widely recognized as a crucial...
6.
Zeng W, Li C, Wu R, Yang X, Wang Q, Lin B, et al.
PLoS Biol
. 2024 Apr;
22(4):e3002591.
PMID: 38652732
Lysosomes are degradation centers of cells and intracellular hubs of signal transduction, nutrient sensing, and autophagy regulation. Dysfunction of lysosomes contributes to a variety of diseases, such as lysosomal storage...
7.
Cong J, Liu P, Han Z, Ying W, Li C, Yang Y, et al.
Immunity
. 2024 Mar;
57(4):876-889.e11.
PMID: 38479384
Concentrations of the secondary bile acid, deoxycholic acid (DCA), are aberrantly elevated in colorectal cancer (CRC) patients, but the consequences remain poorly understood. Here, we screened a library of gut...
8.
Carnosine regulation of intracellular pH homeostasis promotes lysosome-dependent tumor immunoevasion
Yan R, Zhang P, Shen S, Zeng Y, Wang T, Chen Z, et al.
Nat Immunol
. 2024 Jan;
25(3):483-495.
PMID: 38177283
Tumor cells and surrounding immune cells undergo metabolic reprogramming, leading to an acidic tumor microenvironment. However, it is unclear how tumor cells adapt to this acidic stress during tumor progression....
9.
Chen J, Xu N, Qi L, Yan H, Wan F, Gao F, et al.
Cell Rep
. 2023 Dec;
42(12):113573.
PMID: 38096054
Huntington's disease (HD) usually causes cognitive disorders, including learning difficulties, that emerge before motor symptoms. Mutations related to lysosomal trafficking are linked to the pathogenesis of neurological diseases, whereas the...
10.
Li S, Xu X, Li C, Xu Z, Wu K, Ye Q, et al.
Neuroimage
. 2023 Sep;
281:120374.
PMID: 37729795
The study of neural circuits, which underlies perception, cognition, emotion, and behavior, is essential for understanding the mammalian brain, a complex organ consisting of billions of neurons. To study the...