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Chun Hei Antonio Cheung

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Articles 47
Citations 4866
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Recent Articles
1.
Lee C, Lin Y, Chang Y, Chen P, Lin K, Yeh T, et al.
J Cancer . 2025 Feb; 16(5):1694-1708. PMID: 39991577
Acquired resistance to endocrine therapy is a major clinical challenge in the treatment of luminal A [estrogen receptor (ER) and/or progesterone receptor (PR), human epidermal growth factor receptor 2 (ERBB2/HER2),...
2.
Lee K, Chen D, Loh Z, Chung W, Wang C, Chen P, et al.
Cancer Sci . 2024 Oct; 115(12):3973-3985. PMID: 39394900
Germline pathogenic mutation of the BRCA gene increases the prevalence of breast cancer. Reports on the benign variants of BRCA genes are limited. However, the definition of these variants might...
3.
Lin I, Lin Y, Chang Y, Kondapuram S, Lin K, Chen P, et al.
Toxicol Appl Pharmacol . 2024 Mar; 485:116888. PMID: 38452945
Upregulation of the multidrug efflux pump ABCB1/MDR1 (P-gp) and the anti-apoptotic protein BIRC5/Survivin promotes multidrug resistance in various human cancers. GDC-0152 is a DIABLO/SMAC mimetic currently being tested in patients...
4.
Lin J, Song S, Shieh S, Cheung C, Hsu H, Sung C, et al.
R I Med J (2013) . 2023 Sep; 106(9):23-27. PMID: 37768158
Cross-cultural medical education has been suggested to train students to care for diverse patient populations and reform medical education systems. In this article, the authors conduct a cross-cultural comparison between...
5.
Chang Y, Shieh M, Chang Y, Huang W, Su W, Cheng F, et al.
Int J Mol Med . 2022 Jun; 50(2). PMID: 35703361
Cancer cells can acquire resistance to targeted therapeutic agents when the designated targets or their downstream signaling molecules develop protein conformational or activity changes. There is an increasing interest in...
6.
Chen Y, Lee K, Wang C, Shen C, Chen S, Chung W, et al.
Am J Cancer Res . 2022 Jun; 12(5):2084-2101. PMID: 35693094
The incidence of breast cancer is increasing, and is one of the leading causes of cancer death worldwide. Dysregulation of NOTCH1 signaling is reported in breast cancer. In present study,...
7.
Cheng K, Cheung C, Chiang H
Aging Dis . 2022 Jun; 13(3):868-883. PMID: 35656119
Amyloid cascade hypothesis proposes that amyloid β (Aβ) accumulation is the initiator and major contributor to the development of Alzheimer's disease (AD). However, this hypothesis has recently been challenged by...
8.
Chung W, Huang W, Liao W, Hung C, Chiang C, Cheung C, et al.
Sci Rep . 2022 Jan; 12(1):241. PMID: 34997132
The prognosis of patients with human epidermal growth factor receptor 2 (HER2)-positive breast cancer has considerably improved. However, no reliable treatment besides anti-HER2 strategies has been available. FTY720, a small-molecule...
9.
Cheng S, Shieh M, Lin T, Cheung C
J Cell Physiol . 2021 Aug; 237(1):178-188. PMID: 34406646
Dysregulation of DNA damage response/repair and genomic instability promote tumorigenesis and the development of various neurological diseases. Autophagy is a dynamic catabolic process used for removing unnecessary or dysfunctional proteins...
10.
Cheng K, Chen Y, Wu C, Lee W, Cheung C, Chiang H
Mol Neurobiol . 2021 Jul; 58(10):5224-5238. PMID: 34273104
Accumulated beta-amyloid (Aβ) in the brain is the hallmark of Alzheimer's disease (AD). Despite Aβ accumulation is known to trigger cellular dysfunctions and learning and memory damage, the detailed molecular...