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Chun C Fan

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Articles 29
Citations 740
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Recent Articles
1.
Bang L, Bahrami S, Hindley G, Smeland O, Rodevand L, Jaholkowski P, et al.
Transl Psychiatry . 2023 Sep; 13(1):291. PMID: 37658054
Anorexia nervosa (AN) is a heritable eating disorder (50-60%) with an array of commonly comorbid psychiatric disorders and related traits. Although significant genetic correlations between AN and psychiatric disorders and...
2.
Reas E, Shadrin A, Frei O, Motazedi E, McEvoy L, Bahrami S, et al.
Alzheimers Dement . 2023 May; 19(11):5151-5158. PMID: 37132098
Introduction: There is a pressing need for non-invasive, cost-effective tools for early detection of Alzheimer's disease (AD). Methods: Using data from the Alzheimer's Disease Neuroimaging Initiative (ADNI), Cox proportional models...
3.
Hindley G, Frei O, Shadrin A, Cheng W, OConnell K, Icick R, et al.
Am J Psychiatry . 2022 Sep; 179(11):833-843. PMID: 36069018
Objective: Mental disorders are heritable and polygenic, and genome-wide genetic correlations (r) have indicated widespread shared genetic risk across multiple disorders and related traits, mirroring their overlapping clinical characteristics. However,...
4.
Icick R, Shadrin A, Holen B, Karadag N, Lin A, Hindley G, et al.
Neuropsychopharmacology . 2022 Aug; 47(11):1883-1891. PMID: 35953530
Alcohol use disorder (AUD) is a pervasive and devastating mental illness with high comorbidity rates with other mental disorders. Understanding the genetic architecture of this comorbidity could be improved by...
5.
Motazedi E, Cheng W, Thomassen J, Frei O, Rongve A, Athanasiu L, et al.
J Alzheimers Dis . 2022 Jul; 88(4):1533-1544. PMID: 35848024
Background: Polygenic hazard scores (PHS) estimate age-dependent genetic risk of late-onset Alzheimer's disease (AD), but there is limited information about the performance of PHS on real-world data where the population...
6.
Hindley G, OConnell K, Rahman Z, Frei O, Bahrami S, Shadrin A, et al.
Am J Med Genet B Neuropsychiatr Genet . 2022 Jul; 189(6):207-218. PMID: 35841185
Recent genome-wide association studies of mood instability (MOOD) have found significant positive genetic correlation with major depression (DEP) and weak correlations with other psychiatric disorders. We investigated the polygenic overlap...
7.
Pihlstrom L, Fan C, Frei O, Tan M, Karunamuni R, Blauwendraat C, et al.
Mov Disord . 2021 Oct; 37(1):62-69. PMID: 34612543
Background: Parkinson's disease (PD) is a highly age-related disorder, where common genetic risk variants affect both disease risk and age at onset. A statistical approach that integrates these effects across...
8.
Shadrin A, Kaufmann T, van der Meer D, Palmer C, Makowski C, Loughnan R, et al.
Neuroimage . 2021 Sep; 244:118603. PMID: 34560273
Brain morphology has been shown to be highly heritable, yet only a small portion of the heritability is explained by the genetic variants discovered so far. Here we extended the...
9.
Hindley G, Bahrami S, Steen N, OConnell K, Frei O, Shadrin A, et al.
Transl Psychiatry . 2021 Sep; 11(1):466. PMID: 34497263
Increased risk-taking is a central component of bipolar disorder (BIP) and is implicated in schizophrenia (SCZ). Risky behaviours, including smoking and alcohol use, are overrepresented in both disorders and associated...
10.
Bahrami S, Hindley G, Winsvold B, OConnell K, Frei O, Shadrin A, et al.
Brain . 2021 Jul; 145(1):142-153. PMID: 34273149
Migraine is three times more prevalent in people with bipolar disorder or depression. The relationship between schizophrenia and migraine is less certain although glutamatergic and serotonergic neurotransmission are implicated in...