Chuangye Yan
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Explore the profile of Chuangye Yan including associated specialties, affiliations and a list of published articles.
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100
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6642
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Recent Articles
1.
Li J, Liu H, Li J, Liu J, Dai X, Zhu A, et al.
Nat Commun
. 2025 Feb;
16(1):2054.
PMID: 40021629
β-1,3 Glucan synthase (GS) is essential for fungal cell wall biosynthesis. The GS holoenzyme comprises the glycosyltransferase FKS1 and its regulatory factor Rho1, a small GTPase. However, the mechanism by...
2.
Wang T, Huang W, Xu K, Sun Y, Zhang Q, Yan C, et al.
Proc Natl Acad Sci U S A
. 2024 Dec;
122(1):e2423943122.
PMID: 39739783
Despite the recent breakthrough in structure determination and prediction of proteins, the structural investigation of carbohydrates remains a challenge. Here, we report the cryo-EM analysis of a glycofibril found in...
3.
Guo X, Li H, Lu X, Liu H, U K, Yan C, et al.
Nat Struct Mol Biol
. 2024 Dec;
PMID: 39653842
Aberrant activation of Notch signaling, mediated by the Notch intracellular domain (NICD), is linked to certain types of cancer. The NICD is released through γ-secretase-mediated cleavage of the Notch receptor....
4.
Dai X, Liu X, Li J, Chen H, Yan C, Li Y, et al.
Nat Commun
. 2024 Oct;
15(1):9194.
PMID: 39448635
Glycosylphosphatidylinositol (GPI) acyltransferase is crucial for the synthesis of GPI-anchored proteins. Targeting the fungal glycosylphosphatidylinositol acyltransferase GWT1 by manogepix is a promising antifungal strategy. However, the inhibitory mechanism of manogepix...
5.
He J, Liu G, Kong F, Tan Q, Wang Z, Yang M, et al.
Cell Rep
. 2024 Aug;
43(8):114628.
PMID: 39146184
High serum urate levels are the major risk factor for gout. URAT1, the primary transporter for urate absorption in the kidneys, is well known as an anti-hyperuricemia drug target. However,...
6.
Tan J, Xiao Y, Kong F, Zhang X, Xu H, Zhu A, et al.
Nature
. 2024 Jul;
632(8026):921-929.
PMID: 39048818
Noradrenaline, also known as norepinephrine, has a wide range of activities and effects on most brain cell types. Its reuptake from the synaptic cleft heavily relies on the noradrenaline transporter...
7.
Guo X, Li H, Yan C, Lei J, Zhou R, Shi Y
Science
. 2024 Jun;
384(6700):1091-1095.
PMID: 38843321
Successive cleavages of amyloid precursor protein C-terminal fragment with 99 residues (APP-C99) by γ-secretase result in amyloid-β (Aβ) peptides of varying lengths. Most cleavages have a step size of three...
8.
Wang R, Cong Y, Qian D, Yan C, Gong D
Nucleic Acids Res
. 2024 May;
52(11):6718-6727.
PMID: 38742627
The nucleic acid transport properties of the systemic RNAi-defective (SID) 1 family make them attractive targets for developing RNA-based therapeutics and drugs. However, the molecular basis for double-stranded (ds) RNA...
9.
Zhang W, Zhang X, Zhan X, Bai R, Lei J, Yan C, et al.
Cell Res
. 2024 Apr;
34(6):428-439.
PMID: 38658629
Spliceosome is often assembled across an exon and undergoes rearrangement to span a neighboring intron. Most states of the intron-defined spliceosome have been structurally characterized. However, the structure of a...
10.
Huang J, Tao H, Chen J, Shen Y, Lei J, Pan J, et al.
Cell
. 2024 Mar;
187(7):1733-1744.e12.
PMID: 38552612
Mastigonemes, the hair-like lateral appendages lining cilia or flagella, participate in mechanosensation and cellular motion, but their constituents and structure have remained unclear. Here, we report the cryo-EM structure of...