Christos Spanos
Overview
Explore the profile of Christos Spanos including associated specialties, affiliations and a list of published articles.
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Articles
55
Citations
901
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Recent Articles
1.
Zhang H, Kapitonova E, Orrego A, Spanos C, Strachan J, Bayne E
PLoS Genet
. 2025 Mar;
21(3):e1011620.
PMID: 40063661
Heterochromatin is a key feature of eukaryotic genomes that serves important regulatory and structural roles in regions such as centromeres. In fission yeast, maintenance of existing heterochromatic domains relies on...
2.
Idlin N, Krishnamoorthy S, Wolczyk M, Fakhri M, Lechowski M, Stec N, et al.
BMC Biol
. 2025 Jan;
23(1):24.
PMID: 39849491
Background: HuR/ELAV1, a ubiquitous RNA-binding protein, belongs to the RNA-binding protein family and is crucial for stabilizing and regulating the translation of various mRNA targets, influencing gene expression. Elevated HuR...
3.
Bryan E, Valsakumar D, Idigo N, Warburton M, Webb K, McLaughlin K, et al.
Mol Cell
. 2024 Dec;
85(3):471-489.e12.
PMID: 39731917
Promoters of developmental genes in embryonic stem cells (ESCs) are marked by histone H3 lysine 4 trimethylation (H3K4me3) and H3K27me3 in an asymmetric nucleosomal conformation, with each sister histone H3...
4.
Wang M, Robertson D, Zou J, Spanos C, Rappsilber J, Marston A
EMBO J
. 2024 Dec;
44(3):705-735.
PMID: 39690240
Genomes are organised into DNA loops by the Structural Maintenance of Chromosomes (SMC) proteins. SMCs establish functional chromosomal sub-domains for DNA repair, gene expression and chromosome segregation, but how SMC...
5.
Helwak A, Turowski T, Spanos C, Tollervey D
Nat Commun
. 2024 Nov;
15(1):10427.
PMID: 39616178
In the snoRNA host gene SNHG14, 29 consecutive introns each generate SNORD116, and 48 tandem introns encode SNORD115. Loss of SNORD116 expression, but not of SNORD115, is linked to the...
6.
Ludzia P, Ishii M, Deak G, Spanos C, Wilson M, Redfield C, et al.
Structure
. 2024 Nov;
33(1):123-135.e10.
PMID: 39579771
The kinetochore is the macromolecular protein machine that drives chromosome segregation in eukaryotes. In an evolutionarily divergent group of organisms called kinetoplastids, kinetochores are built using a unique set of...
7.
Wapenaar H, Clifford G, Rolls W, Pasquier M, Burdett H, Zhang Y, et al.
EMBO Rep
. 2024 Nov;
25(12):5743-5779.
PMID: 39528729
DNA methyltransferase 3A (DNMT3A) plays a critical role in establishing and maintaining DNA methylation patterns in vertebrates. Here we structurally and biochemically explore the interaction of DNMT3A1 with diverse modified...
8.
Parashara P, Medina-Pritchard B, Abad M, Sotelo-Parrilla P, Thamkachy R, Grundei D, et al.
Science
. 2024 Sep;
385(6713):1098-1104.
PMID: 39236175
Accurate chromosome segregation requires the attachment of microtubules to centromeres, epigenetically defined by the enrichment of CENP-A nucleosomes. During DNA replication, CENP-A nucleosomes undergo dilution. To preserve centromere identity, correct...
9.
Mukherjee A, Spanos C, Marston A
Curr Biol
. 2024 Jul;
34(16):3820-3829.e5.
PMID: 39079532
Gametes are produced via meiosis, a specialized cell division associated with frequent errors that cause birth defects and infertility. Uniquely in meiosis I, homologous chromosomes segregate to opposite poles, usually...
10.
Aktar K, Davies T, Leontiou I, Clark I, Spanos C, Wallace E, et al.
PLoS Genet
. 2024 Jun;
20(6):e1011302.
PMID: 38829899
Cryptococcus neoformans is an opportunistic, human fungal pathogen which undergoes fascinating switches in cell cycle control and ploidy when it encounters stressful environments such as the human lung. Here we...