Christopher Xie
Overview
Explore the profile of Christopher Xie including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
50
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0
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Recent Articles
1.
Mondal D, Xie C, Pascal G, Buraschi S, Iozzo R
Proc Natl Acad Sci U S A
. 2024 Apr;
121(18):e2317760121.
PMID: 38652741
The complex interplay between malignant cells and the cellular and molecular components of the tumor stroma is a key aspect of cancer growth and development. These tumor-host interactions are often...
2.
Xie C, Schaefer L, Iozzo R
iScience
. 2023 Oct;
26(11):108095.
PMID: 37867945
In this comprehensive review, we will dissect the impact of research on proteoglycans focusing on recent developments involved in their synthesis, degradation, and interactions, while critically assessing their usefulness in...
3.
Mondal D, Xie C, Buraschi S, Iozzo R
bioRxiv
. 2023 Sep;
PMID: 37693608
The complex interplay between malignant cells and the cellular and molecular components of the tumor stroma is a key aspect of cancer growth and development. These tumor-host interactions are often...
4.
Chen C, Kapoor A, Xie C, Moss A, Vadigepalli R, Ricard-Blum S, et al.
Matrix Biol
. 2023 Mar;
118:92-109.
PMID: 36907428
The tumor stroma of most solid malignancies is characterized by a pathological accumulation of pro-angiogenic and pro-tumorigenic hyaluronan driving tumorigenesis and metastatic potential. Of all three hyaluronan synthase isoforms, HAS2...
5.
Ventura E, Xie C, Buraschi S, Belfiore A, Iozzo R, Giordano A, et al.
J Exp Clin Cancer Res
. 2022 Dec;
41(1):333.
PMID: 36471440
Background: Mesothelioma is an aggressive disease with limited therapeutic options. The growth factor progranulin plays a critical role in several cancer models, where it regulates tumor initiation and progression. Recent...
6.
Neill T, Xie C, Iozzo R
Am J Physiol Cell Physiol
. 2022 Aug;
323(5):C1355-C1373.
PMID: 36036446
Decorin, a small leucine-rich proteoglycan with multiple biological functions, is known to evoke autophagy and mitophagy in both endothelial and cancer cells. Here, we investigated the effects of soluble decorin...
7.
Xie C, Mondal D, Ulas M, Neill T, Iozzo R
Am J Physiol Cell Physiol
. 2022 Feb;
322(3):C554-C566.
PMID: 35171698
Decorin is a stromal-derived prototype member of the small leucine-rich proteoglycan gene family. In addition to its functions as a regulator of collagen fibrillogenesis and TGF-β activity soluble decorin acts...
8.
A functional outside-in signaling network of proteoglycans and matrix molecules regulating autophagy
Neill T, Kapoor A, Xie C, Buraschi S, Iozzo R
Matrix Biol
. 2021 Apr;
100-101:118-149.
PMID: 33838253
Proteoglycans and selected extracellular matrix constituents are emerging as intrinsic and critical regulators of evolutionarily conversed, intracellular catabolic pathways. Often, these secreted molecules evoke sustained autophagy in a variety of...